Carcinoembryonic antigen-related cell adhesion molecule-20 (CEACAM-20) is a member of the CEACAM subfamily of glycoproteins in the immunoglobulin (Ig) superfamily. Mature human CEACAM-20 consists of a 420 amino acid (aa) extracellular domain (ECD), a 21 aa helical transmembrane segment, and a 114 aa cytoplasmic domain. The extracellular domain possesses four IgC2-like domains which are stabilized by disulfide bonds, as well as several predicted glycosylation sites (1-5). The extracellular domain of CEACAM-20 is also unique among the CEACAMs because it contains a truncated IgV-like N domain (2). Within the ECD, human CEACAM-20 shares 64% and 62% aa identity with the mouse and rat CEACAM-20, respectively. The cytoplasmic domain is unusually long compared to most other CEACAMs and is predicted to contain four tyrosine phosphorylation sites, two of which correspond to the immune-receptor tyrosine-based activation motif (ITAM) (2, 3). Human CEACAM proteins have been linked to numerous intercellular-adhesion and intracellular signaling processes including cell adhesion, growth, and recognition, differentiation, angiogenesis, and apoptosis (7, 8). Human CEACAM-20 expression is limited to the reproductive system and the intestinal tract, with the highest levels of expression found in the small intestine and prostate (2, 3). An in vitro model of human prostate morphogenesis showed that CEACAM-20 is co-expressed with CEACAM-1 and plays a critical role in the formation of prostate organoids, making it a marker for prostate cancer (2). Although the exact mechanism is not fully understood, CEACAM-20 may promote the proliferation of intestinal epithelial cells (IECs) (9). There is evidence suggesting CEACAM-20 can induce the production of chemokines like interleukin (IL)-8 and stimulate inflammatory responses in colitis and Crohn's disease (6). CEACAM-20 is also thought to act as a physiological substrate for SAP-1 in the intestinal epithelium (10).

References

Tchoupa, A. et al. (2014) J Cell Commun Signal 12:27.
Zhang, H. et al. (2013) PLoS ONE 8:e53359.
Zebhauser, R. et al. (2005) Genomics 86:566.
Beauchemin, N. Arabzadeh, A. (2013) Cancer Metastasis Rev 32(3):643.
Kuespert, K. et al. (2006) Curr Opin Cell Biol 18:565.
Murata, Y. et al. (2015) PNAS E4264.
Obrink, B. (1997) Curr Opin Cell Biol 9:616.
Horst, AK. Wagener, C. (2004) Handb Exp Pharmacol 283.
Kitamura, Y. et al. (2015) Genes to Cells 20:578.
Kotani, T. et al. (2016) Expert Review of Gastroenterology & Hepatology. 10:1313.

Long Name

Carcinoembryonic Antigen-related Cell Adhesion Molecule 20

Alternate Names

CEACAM20, GPAD9366, UNQ9366

Entrez Gene IDs

125931 (Human); 71601 (Mouse)

Gene Symbol

CEACAM20

UniProt

Q6UY09-1

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This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

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Human CEACAM-20 Alexa Fluor™ Plus 680-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB9416AFP680

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Background: CEACAM-20