CSN7b Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-38214

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NBP2-38214
NBP2-38214-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (96%), Rat (96%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all CSN7b Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: EWCDGCEAVLLGIEQQVLRANQYKENHNRTQQQVEAEVTNIKKTLKATASSSAQEMEQQLAERECPPHAEQRQPTKKMSKVKGLV

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for CSN7b Antibody - BSA Free

Western Blot: CSN7b Antibody [NBP2-38214]

Western Blot: CSN7b Antibody [NBP2-38214]

Western Blot: CSN7b Antibody [NBP2-38214] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG
Immunohistochemistry: CSN7b Antibody [NBP2-38214]

Immunohistochemistry: CSN7b Antibody [NBP2-38214]

Immunohistochemistry: CSN7b Antibody [NBP2-38214] - Staining of human testis shows strong nuclear and cytoplasmic positivity in cells in seminiferus ducts.
CSN7b Antibody - BSA Free Immunocytochemistry/ Immunofluorescence: CSN7b Antibody [NBP2-38214]

Immunocytochemistry/ Immunofluorescence: CSN7b Antibody [NBP2-38214]

Staining of human cell line A-431 shows localization to nucleoplasm.

Applications for CSN7b Antibody - BSA Free

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: CSN7b

Component of the COP9 signalosome complex (CSN), is a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Alternate Names

Arabidopsis, homolog) subunit 7B, COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis), COP9 signalosome complex subunit 7b, CSN7BMGC111077, FLJ12612, Signalosome subunit 7b

Gene Symbol

COPS7B

UniProt

Q9H9Q2 (Human)

Additional CSN7b Products

Product Documents for CSN7b Antibody - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for CSN7b Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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