Cav3.2 Antibody (S55/10) [PerCP]

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-22444PCP

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Product Datasheet / COA / SDS

View Available Conjugates View Available Formulations

Conjugate

Catalog #

Alexa Fluor 350

NBP1-22444AF350

Alexa Fluor 405

NBP1-22444AF405

Alexa Fluor 488

NBP1-22444AF488

Alexa Fluor 532

NBP1-22444AF532

Alexa Fluor 594

NBP1-22444AF594

Alexa Fluor 647

NBP1-22444AF647

Alexa Fluor 700

NBP1-22444AF700

Alexa Fluor 750

NBP1-22444AF750

Alexa Fluor Plus 405

NBP1-22444AFP405

Alexa Fluor Plus 488

NBP1-22444AFP488

Alexa Fluor Plus 555

NBP1-22444AFP555

Alexa Fluor Plus 594

NBP1-22444AFP594

Alexa Fluor Plus 647

NBP1-22444AFP647

Alexa Fluor Plus 680

NBP1-22444AFP680

Allophycocyanin

NBP1-22444APC

Biotin

NBP1-22444B

CoraFluor 1

NBP1-22444CL1

DyLight 350

NBP1-22444UV

DyLight 405

NBP1-22444V

DyLight 488

NBP1-22444G

DyLight 550

NBP1-22444R

DyLight 594

NBP1-22444DL594

DyLight 650

NBP1-22444C

DyLight 680

NBP1-22444FR

DyLight 755

NBP1-22444IR

FITC

NBP1-22444F

HRP

NBP1-22444H

Janelia Fluor 525

NBP1-22444JF525

Janelia Fluor 549

NBP1-22444JF549

Janelia Fluor 646

NBP1-22444JF646

Janelia Fluor 669

NBP1-22444JF669

mFluor Violet 450 SE

NBP1-22444MFV450

mFluor Violet 500 SE

NBP1-22444MFV500

mFluor Violet 610 SE

NBP1-22444MFV610

PE

NBP1-22444PE

Forumulation

Catalog #

BSA Free

NBP1-22444

Product Specifications
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Western Blot, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Microarray

Label

PerCP (Excitation = 490 nm, Emission = 675 nm)

Antibody Source

Monoclonal Mouse IgG₁ Clone # S55/10

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Cav3.2 Antibodies »

Product Specifications

Immunogen

Fusion protein amino acids 1019-1293 (II-III loop) of human Cav3.2

Localization

Membrane

Specificity

Detects approx 260 kDa. No cross-reactivity against Cav1.3.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG₁

Description

This conjugate is made on demand and is not held in inventory. Each order represents a unique lot. All conjugates are generated using validated conjugation protocols and meet strict degree of labeling (F/P) specifications; additional information is available upon request. The antibody concentration is provided on the individual product label.

For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.

Applications for Cav3.2 Antibody (S55/10) [PerCP]

Application

Recommended Usage

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Frozen

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.

Microarray

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Recommended applications are based on validated applications from the unconjugated base product NBP1-22444. This conjugated antibody is not kept in inventory and is made to order using validated conjugation protocols.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Cav3.2

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inwardrectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). Specifically, Cav3.2 is a protein which in humans is encoded by the CACNA1H gene. Studies suggest certain mutations in this gene lead to childhood absence epilepsy (3, 4). Studies also suggest that the up-regulations of Cav3.2 may participate in the progression of prostate cancer toward an androgen-independent stage (5).

Long Name

Voltage-dependent T-type calcium channel subunit alpha-1H

Alternate Names

CACNA1H, CACNA1HB

Gene Symbol

CACNA1H

Additional Cav3.2 Products

Product Documents for Cav3.2 Antibody (S55/10) [PerCP]

Product Datasheets

Download Product Datasheets

COA

SDS

Product Specific Notices for Cav3.2 Antibody (S55/10) [PerCP]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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