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ATP2C2 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-76567

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NBP1-76567
NBP1-76567-0.025mg
Conjugate
Catalog #

Key Product Details

Species Reactivity

Human, Mouse

Applications

Western Blot, ELISA, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

Product Specifications

Immunogen

Antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human ATP2C2. The immunogen is located within the first 50 amino acids of ATP2C2.

Specificity

At least three isoforms of ATP2C2 are known to exist. ATP2C2 antibody will not cross-react with ATP2C1

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for ATP2C2 Antibody - BSA Free

ATP2C2 Antibody - BSA Free

Western Blot: ATP2C2 Antibody - BSA Free [NBP1-76567] -

Western Blot: ATP2C2 Antibody - BSA Free [NBP1-76567] - Western blot analysis of ATP2C2 in 3T3 cell lysate with ATP2C2 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.
ATP2C2 Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: ATP2C2 Antibody - BSA Free [NBP1-76567] -

Immunocytochemistry/ Immunofluorescence: ATP2C2 Antibody - BSA Free [NBP1-76567] - Immunofluorescence of ATP2C2 in 3T3 cells with ATP2C2 antibody at 20 ug/mL.

Applications for ATP2C2 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

20 ug/ml

Western Blot

1 ug/ml

Reviewed Applications

Read 2 reviews rated 3 using NBP1-76567 in the following applications:

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: ATP2C2

ATP2C2, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 2, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in the related gene ATP2C1 cause Hailey-Hailey disease, for which ATP2C2 does not compensate, suggesting that ATP2C2 plays other physiological roles. Unlike ATP2C1, ATP2C2 has a much more restricted expression pattern and displays a higher maximal turnover rate for overall Ca2+-ATPase reaction and a lower apparent affinity for cytosolic Ca2+ activation of phosphorylation. Overexpression of ATP2C2 in mammary tumors result a Ca2+ influx via the store-operated Ca2+ channel ORAI1 and independent of the STIM1 and STIM2 sensors.

Alternate Names

ATPase 2C2, ATPase, Ca++ transporting, type 2C, member 2, calcium-transporting ATPase type 2C member 2, DKFZp686H22230, KIAA0703, secretory pathway Ca(2+)-ATPase 2, secretory pathway calcium ATPase 2, SPCA2

Gene Symbol

ATP2C2

Additional ATP2C2 Products

Product Documents for ATP2C2 Antibody - BSA Free

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for ATP2C2 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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