Activin B/Inhibin beta B Antibody (24GB6100)
Novus Biologicals, part of Bio-Techne | Catalog # NBP3-51008
Key Product Details
Species Reactivity
Human, Mouse
Applications
Western Blot, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Knockdown Validated
Label
Unconjugated
Antibody Source
Monoclonal Rabbit IgG Clone # 24GB6100
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Product Specifications
Immunogen
A synthesized peptide derived from human Activin B/Inhibin beta B (Uniprot: P09529)
Clonality
Monoclonal
Host
Rabbit
Isotype
IgG
Scientific Data Images for Activin B/Inhibin beta B Antibody (24GB6100)
Immunocytochemistry/ Immunofluorescence: Activin B/Inhibin beta B Antibody (24GB6100)[NBP3-51008] -
Immunocytochemical staining of HT-1080 cells with Activin B/Inhibin beta B antibody (1:1,000) . Nuclei were stained blue with DAPI; Inhibin subunit beta B was stained magenta with Alexa Fluor(R) 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: High. Scale bar, 20 um.
Flow Cytometry: Activin B/Inhibin beta B Antibody (24GB6100)[NBP3-51008] -
Flow cytometric analysis of Activin B/Inhibin beta Bexpression in HT-1080 cells using Activin B/Inhibin beta B antibody (1:2,000). Green, isotype control; red, inhibin subunit beta B.
Western Blot: Activin B/Inhibin beta B Antibody (24GB6100)[NBP3-51008] -
Western blotting analysis using Activin B/Inhibin beta B antibody (1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (1:20,000) respectively. Image was developed using NaQ(TM) ECL Substrate Kit.Applications for Activin B/Inhibin beta B Antibody (24GB6100)
Application
Recommended Usage
Flow Cytometry
Optimal dilutions of this antibody should be experimentally determined.
Immunocytochemistry/ Immunofluorescence
Optimal dilutions of this antibody should be experimentally determined.
Knockdown Validated
Optimal dilutions of this antibody should be experimentally determined.
Western Blot
Optimal dilutions of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Affinity purified
Formulation
PBS (pH 7.4), 50% glycerol
Preservative
0.02% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at -20C. Avoid freeze-thaw cycles.
Background: Activin B
Activin B is a TGF-beta superfamily cytokine that regulates cellular migration by inducing actin stress fiber formation. It signals through heterodimeric receptor complexes composed of type I (Activin RIA or RIB) and type II (Activin RIIA or RIIB) transmembrane Ser/Thr kinases. It also modulates signaling through E-Cadherin and Integrin beta 3. Activin B upregulation is associated with tumor cell adhesion, migration, and metastasis. It also promotes wound healing through increased cellular migration. Activin B additionally induces hair follicle formation and expression of Hepicin in the liver, but it inhibits lipolysis in adipocytes and glucose-stimulated calcium influx in pancreatic beta cells. Alterations of Activin B serum levels of Activin B are associated with ectopic pregnancy and chronic fatigue syndrome, and it is upregulated in alveolar epithelial cells in pulmonary fibrosis.
Alternate Names
activin AB beta polypeptide, Activin beta-B chain, INHBB, inhibin beta B chain, inhibin, beta B, inhibin, beta B (activin AB beta polypeptide), Inhibin, beta-2
Gene Symbol
INHBB
Additional Activin B Products
Product Documents for Activin B/Inhibin beta B Antibody (24GB6100)
Product Specific Notices for Activin B/Inhibin beta B Antibody (24GB6100)
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
Loading...
Loading...
Loading...
Loading...
Loading...