Nicotinic Acetylcholine R alpha 4/CHRNA4: Small Molecules and Peptides
CHRNA4 is a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. CHRNA4 is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in CHRNA4 cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in CHRNA4 that provide protection against nicotine addiction have been described.
13 results for "Nicotinic Acetylcholine R alpha 4/CHRNA4 Small Molecules and Peptides" in Products
13 results for "Nicotinic Acetylcholine R alpha 4/CHRNA4 Small Molecules and Peptides" in Products
Nicotinic Acetylcholine R alpha 4/CHRNA4: Small Molecules and Peptides
CHRNA4 is a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. CHRNA4 is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in CHRNA4 cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in CHRNA4 that provide protection against nicotine addiction have been described.
α4β2, muscle type and Torpedo nAChR antagonist
| Alternate Names: | DHβE |
| Chemical Name: | (2S,13bS)-2-Methoxy-2,3,5,6,8,9,10,13-octahydro-1H,12H-benzo[i]pyrano[3,4-g]indolizin-12-one hydrobromide |
| Purity: | ≥98% (HPLC) |
α4β2 nAChR ligand; may act as an agonist or a desensitizer
| Chemical Name: | 6-[5-[(2S)-2-Azetidinylmethoxy]-3-pyridinyl]-5-hexyn-1-ol dihydrochloride |
| Purity: | ≥98% (HPLC) |
Selective α4β2 nAChR agonist
| Alternate Names: | Metanicotine,TC-2403 |
| Chemical Name: | (E)-N-Methyl-4-(3-pyridinyl)-3-buten-1-amine oxalate |
| Purity: | ≥99% (HPLC) |
Selective α4β2 nAChR partial agonist
| Chemical Name: | 4-(5-ethoxy-3-pyridinyl)-N-methyl-(3E)-3-buten-1-amine difumarate |
| Purity: | ≥98% (HPLC) |
Selective α4β2 nAChR agonist
| Alternate Names: | Tebanicline |
| Chemical Name: | (R)-5-(Azetidin-2-ylmethoxy)-2-chloropyridine hydrochloride |
| Purity: | ≥98% (HPLC) |
Selective α4β2 nAChR partial agonist; orally active
| Chemical Name: | 7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine tartrate |
| Purity: | ≥99% (HPLC) |
Potent α4β4, α4β2 and α7 nAChR agonist
| Chemical Name: | (1R,5S)-9-Bromo-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one |
| Purity: | ≥98% (HPLC) |
High affinity and subtype-selective α6β2 and α4β2 nAChR partial agonist
| Chemical Name: | (1R,5S)-1,2,3,4,5,6-Hexahydro-3-[2-[(1R,5S)-1,5,6,8-tetrahydro-8-oxo-1,5-methano-2H-pyrido[1,2-a][1,5]diazocin-3(4H)-yl]ethyl]-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one |
| Purity: | ≥98% (HPLC) |
High affinity and selective α4β2 nAChR partial agonist
| Chemical Name: | 2-Methyl-3-[(2S)-pyrrolidinylmethoxy]pyridine dihydrochloride |
| Purity: | ≥98% (HPLC) |
Positive allosteric modulator of α4β2 nAChRs; also muscle-type nAChR inhibitor
| Chemical Name: | 6-Bromo-2-(1,1-dimethyl-2-propenyl)-N-1H-indole-3-ethanamine hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent and selective neuronal nAChRagonist
| Chemical Name: | (1R,5S)-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one |
| Purity: | ≥99% (HPLC) |
Potent positive allosteric modulator of α4β2 nAChRs; also inhibitor of (α4)2(β2)3, muscle-type and Torpedo nAChRs
| Chemical Name: | 3-(2-Chlorophenyl)-5-(5-methyl-1-(piperidin-4-yl)-1H-pyrazol-4-yl)isoxazole hydrochloride |
| Purity: | ≥98% (HPLC) |
Positive allosteric modulator of α4β2 nAChRs
| Chemical Name: | 3-[3-(3-Pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile |
| Purity: | ≥98% (HPLC) |
