Varenicline tartrate

Tocris Bioscience, part of Bio-Techne | Catalog # 3754

Selective α4β2 nAChR partial agonist; orally active
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Key Product Details

Description

Selective α4β2 nAChR partial agonist; orally active

View all Nicotinic (a4b2) Receptor Agonists »

Product Description

Varenicline tartrate is an orally active, subtype-selective partial agonist at α4β2 nicotinic receptors (Ki values are 0.06, 240, 322 and 3540 nM for α4β2, α3β4, α7, α1βγδ receptors respectively). Reduces nicotine-evoked dopamine release in vitro and decreases nicotine self-administration in vivo. Also potently activates PSAM4-5-HT3 and PSAM4-GlyR chimeric ion channels (EC50 values are 4 and 1.6 nM, respectively)

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications

Molecular Weight

361.37

Formula

C13H13N3.C4H6O6

Storage

Desiccate at RT

Purity

≥99% (HPLC)

Chemical Name

7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine tartrate

CAS Number

375815-87-5

PubChem ID

5310966

InChI Key

JQSHBVHOMNKWFT-DTORHVGOSA-N

SMILES

OC(C(O)C(O)=O)C(O)=O.C1(C=C([C@H]4CNC[C@@H]3C4)C3=C2)=C2N=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 36.14 100
DMSO 18.07 50

Preparing Stock Solutions for Varenicline tartrate

The following data is based on the product molecular weight 361.37

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.84 mL 27.67 mL
5 mM 0.55 mL 2.77 mL 5.53 mL
10 mM 0.28 mL 1.38 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for Varenicline tartrate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Varenicline tartrate

For research use only

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