RJR 2403 oxalate
Tocris Bioscience, part of Bio-Techne | Catalog # 1053
Selective α4β2 nAChR agonist
Key Product Details
Description
Selective α4β2 nAChR agonist
Alternative Names
Metanicotine,TC-2403
Product Description
RJR 2403 oxalate is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki values are 26 and 36000 nM for α4β2 and α7 receptors respectively). Active in vivo.Product Specifications
Molecular Weight
252.27
Formula
C10H14N2.C2H2O4
Storage
Desiccate at +4°C
Purity
≥99% (HPLC)
Chemical Name
(E)-N-Methyl-4-(3-pyridinyl)-3-buten-1-amine oxalate
CAS Number
220662-95-3
PubChem ID
23298272
InChI Key
WTIZFOAIQXMQHC-DPZBITMOSA-N
SMILES
O=C(O)C(O)=O.CNCC/C=C/C1=CC=CN=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 25.23 | 100 |
Preparing Stock Solutions
for RJR 2403 oxalate
The following data is based on the product molecular weight 252.27
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.96 mL | 19.82 mL | 39.64 mL |
| 5 mM | 0.79 mL | 3.96 mL | 7.93 mL |
| 10 mM | 0.40 mL | 1.98 mL | 3.96 mL |
| 50 mM | 0.08 mL | 0.40 mL | 0.79 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Damaj Antinociceptive and pharmacological effects of metanicotine, a selective nicotinic agonist. J.Pharmacol.Exp.Ther. 1999 PMID: 10490929
- Lippiello RJR-2403: a nicotinic agonist with CNS selectivity II. In vivo characterization. J.Pharmacol.Exp.Ther. 1996 PMID: 8968367
- Bencherif RJR-2403: a nicotinic agonist with CNS selectivity I. In vitro characterization. J.Pharmacol.Exp.Ther. 1996 PMID: 8968366
Product Specific Notices for RJR 2403 oxalate
For research use only
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