RJR 2403 oxalate

Name: RJR 2403 oxalate
Brand: Tocris Bioscience
SKU: 1053

Tocris Bioscience, part of Bio-Techne | Catalog # 1053

Citations (12)

COA / SDS

Selective α4β2 nAChR agonist

Key Product Details

Description:	Selective α4β2 nAChR agonist
Alternative Names:	Metanicotine,TC-2403
Chemical Name:	(E)-N-Methyl-4-(3-pyridinyl)-3-buten-1-amine oxalate
Purity:	≥99% (HPLC)
Molecular Weight:	252.27

View Full Technical Details for RJR 2403 oxalate

Technical Data
Citations

Biological Activity for RJR 2403 oxalate

RJR 2403 oxalate is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (K_i values are 26 and 36000 nM for α4β2 and α7 receptors respectively). Active in vivo.

Technical Data for RJR 2403 oxalate

M. Wt	252.27
Formula	C₁₀H₁₄N₂.C₂H₂O₄
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	220662-95-3
PubChem ID	23298272
InChi Key	WTIZFOAIQXMQHC-DPZBITMOSA-N
Smiles	O=C(O)C(O)=O.CNCC/C=C/C1=CC=CN=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RJR 2403 oxalate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	25.23	100

Preparing Stock Solutions for RJR 2403 oxalate

The following data is based on the product molecular weight 252.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.96 mL	19.82 mL	39.64 mL
5 mM	0.79 mL	3.96 mL	7.93 mL
10 mM	0.40 mL	1.98 mL	3.96 mL
50 mM	0.08 mL	0.40 mL	0.79 mL

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References for RJR 2403 oxalate

References are publications that support the biological activity of the product.

Damaj Antinociceptive and pharmacological effects of metanicotine, a selective nicotinic agonist. J.Pharmacol.Exp.Ther. 1999 PMID: 10490929
Lippiello RJR-2403: a nicotinic agonist with CNS selectivity II. In vivo characterization. J.Pharmacol.Exp.Ther. 1996 PMID: 8968367
Bencherif RJR-2403: a nicotinic agonist with CNS selectivity I. In vitro characterization. J.Pharmacol.Exp.Ther. 1996 PMID: 8968366