NS 9283

Name: NS 9283
Brand: Tocris Bioscience
SKU: 5112

Tocris Bioscience, part of Bio-Techne | Catalog # 5112

Citations (12)

COA / SDS

Positive allosteric modulator of α4β2 nAChRs

Key Product Details

Description:	Positive allosteric modulator of α4β2 nAChRs
Chemical Name:	3-[3-(3-Pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile
Purity:	≥98% (HPLC)
Molecular Weight:	248.24

View Full Technical Details for NS 9283

Technical Data
Citations

Biological Activity for NS 9283

NS 9283 is a positive allosteric modulator of α4β2 receptor; increases the potency of Ach-evoked currents ~60 fold without affecting the maximum efficacy (HEK293-hα4β2 cells). Reduces the rate of recovery from desensitization and slows the rate of deactivation. Displays a synergistic effect on the E_max when given with NS206 at 3α:2β receptors.

Compound Libraries for NS 9283

NS 9283 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NS 9283

M. Wt	248.24
Formula	C₁₄H₈N₄O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	913830-15-6
PubChem ID	11998180
InChi Key	HGFXDSQLRSWUBO-UHFFFAOYSA-N
Smiles	N#CC1=CC(C2=NC(C3=CN=CC=C3)=NO2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NS 9283

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	12.41	50
	1eq. HCl	4.96	20

Preparing Stock Solutions for NS 9283

The following data is based on the product molecular weight 248.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	8.06 mL	40.28 mL	80.57 mL
2.5 mM	1.61 mL	8.06 mL	16.11 mL
5 mM	0.81 mL	4.03 mL	8.06 mL
25 mM	0.16 mL	0.81 mL	1.61 mL

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References for NS 9283

References are publications that support the biological activity of the product.

Mohler Discriminative-stimulus effects of NS9283, a nicotinic α4β2* positive allosteric modulator, in nicotine-discriminating rats. Psychopharmacology (Berl). 2014 PMID: 23925734
Olsen Two distinct allosteric binding sites at α4β2 nicotinic acetylcholine receptors revealed by NS206 and NS9283 give unique insights to binding activity-associated linkage at Cys-loop receptor J.Biol.Chem. 2013 PMID: 24169695
Grupe Unravelling the mechanism of action of NS9283, a positive allosteric modulator of (α4)3(β2)2 nicotinic ACh receptors. Br.J.Pharmacol. 2013 PMID: 23278456