Integrin Receptor Inhibitors: Small Molecules and Peptides
Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM). Integrins have diverse roles in several biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Their activities can also regulate the metastatic and invasive potential of tumor cells. They exist as heterodimers consisting of alpha and beta subunits. Some alpha and beta subunits exhibit specificity for one another and may be designated as a VLA (very late antigen) member. Heterodimers often preferentially bind certain cell adhesion molecules, or constituents of the ECM. Although they have no catalytic activity, integrins can be part of multimolecular signaling complexes known as focal adhesions.
20 results for "Integrin Receptor Inhibitors Small Molecules and Peptides" in Products
20 results for "Integrin Receptor Inhibitors Small Molecules and Peptides" in Products
Integrin Receptor Inhibitors: Small Molecules and Peptides
Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM). Integrins have diverse roles in several biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Their activities can also regulate the metastatic and invasive potential of tumor cells. They exist as heterodimers consisting of alpha and beta subunits. Some alpha and beta subunits exhibit specificity for one another and may be designated as a VLA (very late antigen) member. Heterodimers often preferentially bind certain cell adhesion molecules, or constituents of the ECM. Although they have no catalytic activity, integrins can be part of multimolecular signaling complexes known as focal adhesions.
Integrin binding sequence; inhibits integrin receptor function
| Purity: | ≥95% (HPLC) |
Potent and selective inhibitor of integrins αvβ3 and αvβ5
| Alternate Names: | EMD121974 |
| Purity: | ≥95% (HPLC) |
α5β1 integrin receptor antagonist
| Purity: | ≥95% (HPLC) |
Glycoprotein IIb/IIIa (integrin αIIbβ3) receptor antagonist. Antithrombotic
| Chemical Name: | 4-[4-[4-(Aminoiminomethyl)phenyl]-1-piperazinyl]-1-piperidineacetic acid trihydrochloride |
| Purity: | ≥98% (HPLC) |
Minimal recognition sequence for integrin binding; potent integrin inhibitor
| Purity: | ≥95% (HPLC) |
Potent and selective α5β1 integrin inhibitor
| Chemical Name: | N-(2,6-Dimethylbenzoyl)-O-[3-(2-pyridinylamino)propyl]-L-tyrosine |
| Purity: | ≥98% (HPLC) |
ανβ6 integrin inhibitor
| Chemical Name: | N-[1-Oxo-5-(2-pyridinylamino)pentyl]-O-(phenylmethyl)-L-seryl-3-(3,5-dichlorophenyl)-β-alanine hydrochloride |
| Purity: | ≥98% (HPLC) |
α2 integrin inhibitor; anti-angiogenic
| Chemical Name: | 3-Cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide |
| Purity: | ≥98% (HPLC) |
Highly potent and selective inhibitor of integrin α4β1 (VLA-4)
| Chemical Name: | (2S)-2-[[[(2S)-1-[(3,5-Dichlorophenyl)sulfonyl]-2-pyrrolidinyl]carbonyl]amino]-4-[[(2S)-4-methyl-2-[methyl[2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl]amino]-1-oxopentyl]amino]butanoic acid |
| Purity: | ≥98% (HPLC) |
Potent inhibitor of the LFA-1/ICAM-1 interaction
| Chemical Name: | (2E)-1-(4-Acetyl-1-piperazinyl)-3-[4-[[2-(1-methylethyl)phenyl]thio]-3-nitrophenyl]-2-propen-1-one |
| Purity: | ≥98% (HPLC) |
Selective inhibitor of integrin α2β1
| Chemical Name: | 1-(4-Fluorophenyl)-N-methyl-N-[4[[(phenylamino)carbonyl]amino]phenyl]-1H-pyrazole-4-sulfonamide |
| Purity: | ≥98% (HPLC) |
αVβ3 and glycoprotein IIb/IIIa (integrin αIIbβ3) inhibitor
| Purity: | ≥95% (HPLC) |
Potent αv integrin inhibitor
| Chemical Name: | 3-[[2,5-Dimethyl-6-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)-1-piperidinyl]-4-pyrimidinyl]amino]-N-[(4-methoxyphenyl)sulfonyl]-L-alanine |
| Purity: | ≥97% (HPLC) |
Potent and selective α1β1 inhibitor
| Purity: | ≥95% (HPLC) |
Selective α4β1 (VLA-4) inhibitor
| Purity: | ≥95% (HPLC) |
Potent α2β1 inhibitor; displays antithrombotic activity in vivo
| Chemical Name: | N-[[(4R)-5,5-Dimethyl-3-(phenylsulfonyl)-4-thiazolidinyl]carbonyl]-3-[[[(phenylmethyl)amino]carbonyl]amino]-L-alanine |
| Purity: | ≥98% (HPLC) |
Potent inhibitor of the LFA-1/ICAM interaction
| Chemical Name: | 6-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4,4]non-7-yl]-3-pyridinecarboxylic acid |
| Purity: | ≥98% (HPLC) |
Potent integrin α4β7 and α4β1 (VLA-4) antagonist; orally bioavailable
| Chemical Name: | (αS)-α-[(2,6-Dichlorobenzoyl)amino]-2',6'-dimethoxy[1,1'-biphenyl]-4-propanoic acid |
| Purity: | ≥98% (HPLC) |
Potent negative allosteric modulator of LFA-1
| Chemical Name: | (5R)-5-[(4-Bromophenyl)methyl]-3-(3,5-dichlorophenyl)-1,5-dimethyl-2,4-imidazolidinedione |
| Purity: | ≥98% (HPLC) |
α4β1 (VLA-4) antagonist
| Chemical Name: | 1-[[(3S)-4-[2-[4-[[[(2-Methylphenyl)amino]carbonyl]amino]phenyl]acety]l-3-morpholinyl]carbonyl]-4-piperidinediacetic acid |
| Purity: | ≥98% (HPLC) |
