E 7820

Tocris Bioscience, part of Bio-Techne | Catalog # 6785

α2 integrin inhibitor; anti-angiogenic
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Key Product Details

Description

α2 integrin inhibitor; anti-angiogenic

View all Integrin Receptor Inhibitors »

Product Description

E 7820 is a α2 integrin inhibitor. Inhibits angiogenesis in vitro (IC50 = 0.11 - 0.25 μM). Also inhibits growth of human colorectal cancer cell lines. Enhances efficacy of erlotinib in a non-small-cell lung cancer xenograft model. Also acts as a molecular glue to induce proteosomal degradation of mRNA splicing factor RBM39.

Product Specifications

Molecular Weight

336.37

Formula

C17H12N4O2S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

3-Cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide

CAS Number

289483-69-8

PubChem ID

196970

InChI Key

LWGUASZLXHYWIV-UHFFFAOYSA-N

SMILES

CC1=C2C(C#N)=CNC2=C(C=C1)NS(=O)(C3=CC(C#N)=CC=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.64 100

Preparing Stock Solutions for E 7820

The following data is based on the product molecular weight 336.37

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.97 mL 14.86 mL 29.73 mL
5 mM 0.59 mL 2.97 mL 5.95 mL
10 mM 0.30 mL 1.49 mL 2.97 mL
50 mM 0.06 mL 0.30 mL 0.59 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for E 7820

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for E 7820

For research use only

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