ATN 161
Tocris Bioscience, part of Bio-Techne | Catalog # 6058
α5β1 integrin receptor antagonist
Key Product Details
Description
α5β1 integrin receptor antagonist
Product Description
ATN 161 is a α5β1 integrin receptor antagonist. Reduces liver metastasis and improves survival in combination with 5-FU (Cat. No. 3257) in a mouse model of colon cancer. Reduces MLL tumor growth in rats and decreases tumor volume of human MDA-MB-231 cell xenografts in mice.Product Specifications
Molecular Weight
597.65
Formula
C23H35N9O8S
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
262438-43-7
PubChem ID
9960285
InChI Key
MMHDBUJXLOFTLC-WOYTXXSLSA-N
SMILES
CC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(N)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 2mg/ml in water |
Calculators
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Background References
References are publications that support the biological activity of the product.
- Khalili A non-RGD-based integrin binding peptide (ATN-161) blocks breast cancer growth and metastasis in vivo. Mol.Cancer Ther. 2006 PMID: 16985061
- Stoeltzing Inhibition of integrin α5β1 function with a small peptide (ATN-161) plus continuous 5-FU infusion reduces colorectal liver metastases and improves survival in mice. Int.J.Cancer. 2003 PMID: 12584749
- Livant Anti-invasive, antitumorigenic, and antimetastatic activities of the PHSCN sequence in prostate carcinoma. Cancer Res. 2000 PMID: 10667582
Product Specific Notices for ATN 161
For research use only
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