RGD peptide
Tocris Bioscience, part of Bio-Techne | Catalog # 7723
Minimal recognition sequence for integrin binding; potent integrin inhibitor
Key Product Details
Description
Minimal recognition sequence for integrin binding; potent integrin inhibitor
Product Description
RGD peptide is a potent integrin inhibitor (IC50 values are 89, 335 and 440 nM for αvβ3, α5β1 and αvβ5, respectively). RGD is the minimal recognition sequence for integrin binding found in many extracellular matrix (ECM) and serum proteins. RGD peptide is used for directing association of various cell types with diverse biomaterials. The functionality of RGD peptide is usually maintained throughout the processing and sterilization steps required for biomaterials synthesis. RGD peptide can be incorporated into hyaluronic acid hydrogel for human mesenchymal stem cells (hMSCs) delivery. RGD peptide significantly increases hMSC spreading and protein secretion under standard or ischemic culture conditions. RGD peptide can also be incorporated into alginate bioink for 3D bioprinting of MSCs onto cartilage templates for bone organogenesis.Product Specifications
Molecular Weight
346.34
Formula
C12H22N6O6
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
99896-85-2
PubChem ID
104802
InChI Key
IYMAXBFPHPZYIK-BQBZGAKWSA-N
SMILES
O=C(NCC(N[C@@H](CC(O)=O)C(O)=O)=O)[C@H](CCCNC(N)=N)N
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 10mg/ml in water |
Calculators
Molarity Calculator
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Background References
References are publications that support the biological activity of the product.
- Daly 3D bioprinting of developmentally inspired templates for whole bone organ engineering. Adv.Healthc.Mater. 2016 PMID: 27281607
- Gallagher Pre-culture of mesenchymal stem cells within RGD-modified hyaluronic acid hydrogel improves their resilience to ischaemic conditions. Acta.Biomater. 2020 PMID: 32145393
- Ruoslahti New perspectives in cell adhesion: RGD and integrins. Science 1987 PMID: 2821619
- Kapp A comprehensive evaluation of the activity and selectivity profile of ligands for RGD-binding integrins. Sci.Rep. 2017 PMID: 28074920
- Bellis Advantages of RGD peptides for directing cell association with biomaterials. Biomaterials 2011 PMID: 21515168
Product Specific Notices for RGD peptide
For research use only
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