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121 results for "CRBN Small Molecules and Peptides" in Products

CRBN: Small Molecules and Peptides

Modulates cell surface expression of KCNT1 . May be involved in memory and learning

Cereblon Degrader (PROTAC®)

Chemical Name: N1-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-N20-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,9,12,18-tetraoxaicosanediamide
Purity: ≥98% (HPLC)
Cereblon Degrader (PROTAC®)

Potent and selective cereblon Degrader (PROTAC®); cell-permeable

Chemical Name: (2S,4R)-1-((2S)-2-(5-((5-((6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)oxy)pentyl)oxy)pentanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥96% (HPLC)
Application of CRBN-6-5-5-VHL in MM1S cells for CRBN-6-5-5-VHL
(2)

Potent and selective Wee1 Degrader (PROTAC®)

Chemical Name: 4-((3-(4-(4-((2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)propyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
Purity: ≥98% (HPLC)
Potent and selective Wee1 Degrader (PROTAC®)

Cereblon ligand with PEG linker and terminal amine for onward chemistry

Alternate Names: Pomalidomide - linker 8
Chemical Name: 4-[(14-Amino-3,6,9,12-tetraoxatetradec-1-yl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione hydrochloride
Purity: ≥95% (HPLC)
Cereblon ligand with PEG linker and terminal amine for onward chemistry

Negative control for dTAG-13 (Cat. No. 6605)

Chemical Name: 1-[(2S)-1-Oxo-2-(3,4,5-trimethoxyphenyl)butyl]-(2S)-2-piperidinecarboxylate (1R)-3-(3,4-dimethoxyphenyl)-1-[2-[2-[[6-[[2-(1-methyl-2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]hexyl]amino]-2-oxoethoxy]phenyl]propyl ester
Purity: ≥97% (HPLC)
Negative control for dTAG-13 (Cat. No. 6605)

Cereblon ligand with PEG linker and terminal amine for onward chemistry

Alternate Names: Thalidomide - linker 1
Chemical Name: N-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide hydrochloride
Purity: ≥95% (HPLC)
Cereblon ligand with PEG linker and terminal amine for onward chemistry

Binds cereblon; also TNF-α synthesis inhibitor

Chemical Name: N-(2,6-dioxo-3-piperidinyl)phthalimide
Purity: ≥98% (HPLC)
Binds cereblon; also TNF-α synthesis inhibitor

Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase

Chemical Name: 3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione
Purity: ≥98% (HPLC)
Cereblon binder; induces ubiquitination and degradation of CK1α by  E3 ubiquitin ligase

Cereblon ligand with terminal piperidine for onward chemistry

Chemical Name: 2-(2,6-Dioxo-3-piperidinyl)-5-fluoro-6-[4-(4-piperidinylmethyl)-1-piperazinyl]-1H-isoindole-1,3(2H)-dione dihydrochloride
Purity: ≥95% (HPLC)
Cereblon ligand with terminal piperidine for onward chemistry

Functionalized cereblon ligand for PROTAC development

Chemical Name: 3-[[3-(1-Piperazinyl)phenyl]amino]-2,6-piperidinedione dihydrochloride
Purity: ≥95% (HPLC)
Functionalized cereblon ligand for PROTAC development

Functionalized cereblon ligand for generating Degrader negative controls; also used as Pomalidomide negative control

Chemical Name: 4-Amino-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Purity: ≥95% (HPLC)
Functionalized cereblon ligand for generating Degrader negative controls; also used as Pomalidomide negative control

Potent and selective BTK Degrader (PROTAC®)

Chemical Name: 3-[[4-[1-[[1-[6-[[[(3S)-2,6-Dioxo-3-piperidinyl]amino]carbonyl]-3-pyridinyl]-4-piperidinyl]methyl]-4-piperidinyl]phenyl]amino]-5-[(3R)-3-(3-methyl-2-oxo-1-imidazolidinyl)-1-piperidinyl]-2-pyrazinecarboxamide
Purity: ≥98% (HPLC)
Selective BTK Degrader

Functionalized cereblon ligand for PROTAC development

Chemical Name: 2-(4-(2,6-Dioxopiperidin-3-yl)phenoxy)acetic acid
Purity: ≥95% (HPLC)
Functionalized cereblon ligand for PROTAC development

Cereblon ligand with PEG linker and terminal azide for onward chemistry

Chemical Name: 3-[4-[[2-(2-Azidoethoxy)ethyl]amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-2,6-piperidinedione
Purity: ≥95% (HPLC)
Cereblon ligand with PEG linker and terminal azide for onward chemistry

Cereblon ligand with PEG linker and terminal amine for onward chemistry

Chemical Name: 5-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride
Purity: ≥95% (HPLC)
Cereblon ligand with PEG linker and terminal amine for onward chemistry

Cereblon ligand with alkyl linker and terminal azide for onward chemistry

Chemical Name: 4-[(2-Azidoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Purity: ≥95% (HPLC)
Cereblon ligand with alkyl linker and terminal azide for onward chemistry

Cereblon ligand with terminal piperidine for onward chemistry

Chemical Name: 2-(2,6-Dioxo-3-piperidinyl)-5-[4-(4-piperidinylmethyl)-1-piperazinyl]-1H-isoindole-1,3(2H)-dione dihydrochloride
Purity: ≥95% (HPLC)
Cereblon ligand with terminal piperidine for onward chemistry

Functionalized cereblon ligand for PROTAC development

Chemical Name: 3-[[3-Fluoro-4-(1-piperazinyl)phenyl]amino]-2,6-piperidinedione dihydrochloride
Purity: ≥95% (HPLC)
Functionalized cereblon ligand for PROTAC development

BET bromodomain Degrader (PROTAC®); also potent Hedgehog pathway inhibitor

Chemical Name: 2-Methoxyethyl 4-(3-((1-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)hexyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate
Purity: ≥98% (HPLC)
BET bromodomain Degrader; also potent Hedgehog pathway inhibitor

Functionalized cereblon ligand for PROTAC development

Chemical Name: 2-[4-(Tetrahydro-2,4-dioxo-1(2H)-pyrimidinyl)phenoxy]acetic acid
Purity: ≥95% (HPLC)
Functionalized cereblon ligand for PROTAC development

Potent and selective cereblon-recruiting Degrader (PROTAC®) of mutant EGFR

Chemical Name: 3-(4-(3-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)-N-(8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)octyl)propanamide
Purity: ≥98% (HPLC)
Potent and selective cereblon-recruiting Degrader (PROTAC®) of mutant EGFR

Stable cereblon ligand, for PROTAC synthesis

Chemical Name: Dihydro-1-[4-(1-piperazinyl)phenyl]-2,4(1H,3H)-pyrimidinedione dihydrochloride
Purity: ≥95% (HPLC)
Stable cereblon ligand, for PROTAC synthesis

Cereblon ligand with terminal piperazine for onward chemistry

Chemical Name: 2-(2,6-Dioxo-3-piperidinyl)-5-(1-piperazinyl)-1H-isoindole-1,3(2H)-dione hydrochloride
Purity: ≥95% (HPLC)
Cereblon ligand with terminal piperazine for onward chemistry

Potent covalent inhibitor of Cereblon

Chemical Name: 2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-3-oxo-1H-isoindole-5-sulfonyl fluoride
Purity: ≥95% (HPLC)
Potent covalent inhibitor of Cereblon

Potent and selective AR and AR L702H Degrader, orally bioavailable

Chemical Name: 4-[4-[4-[4-[[4-[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-7-methoxy-1-oxo-1H-isoindol-5-yl]-1-piperazinyl]methyl]-1-piperidinyl]phenyl]-1-piperidinyl]-3-fluoro-2-(trifluoromethyl)benzonitrile
Purity: ≥98% (HPLC)
Potent and selective AR and AR L702H Degrader, orally bioavailable
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