PD 4'-oxyacetic acid

Tocris Bioscience, part of Bio-Techne | Catalog # 7858

Functionalized cereblon ligand for PROTAC development
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Key Product Details

Description

Functionalized cereblon ligand for PROTAC development

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Product Description

PD 4'-oxyacetic is a carboxylic acid-functionalized cereblon ligand that can be used for PROTAC® Degrader development. The compound can be used to develop PD-PROTACs that exhibit improved stability and potency compared with PROTACs synthesized using IMiD (immunomodulatory imide drug) analogs.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Product Specifications

Molecular Weight

264.24

Formula

C12H12N2O5

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

2-[4-(Tetrahydro-2,4-dioxo-1(2H)-pyrimidinyl)phenoxy]acetic acid

CAS Number

2633633-12-0

InChI Key

QZLQKDIAPJHBAU-UHFFFAOYSA-N

SMILES

O=C(COC1=CC=C(N2C(NC(CC2)=O)=O)C=C1)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Calculators

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Background References

References are publications that support the biological activity of the product.

  • Jarusiewicz Phenyl dihydrouracil: an alternative cereblon binder for PROTAC design. ACS Med.Chem.Lett.

Product Documents for PD 4'-oxyacetic acid

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PD 4'-oxyacetic acid

For research use only

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