Thalidomide 4'-oxyacetamide-PEG3-amine

Name: Thalidomide 4'-oxyacetamide-PEG3-amine
Brand: Tocris Bioscience
SKU: 6467
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 6467

COA / SDS

Cereblon ligand with PEG linker and terminal amine for onward chemistry

Key Product Details

Description:	Cereblon ligand with PEG linker and terminal amine for onward chemistry
Alternative Names:	Thalidomide - linker 1
Chemical Name:	N-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide hydrochloride
Purity:	≥95% (HPLC)
Molecular Weight:	542.97

View Full Technical Details for Thalidomide 4'-oxyacetamide-PEG3-amine

Technical Data
Citations

Biological Activity for Thalidomide 4'-oxyacetamide-PEG3-amine

Thalidomide 4'-oxyacetamide-PEG3-amine is a functionalized cereblon ligand for PROTACsup>® research and development; incorporates an E3 ligase ligand plus a PEG linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

This product has been recently renamed. The previous name for this product was Thalidomide - linker 1

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for Thalidomide 4'-oxyacetamide-PEG3-amine

M. Wt	542.97
Formula	C₂₃H₃₀N₄O₉.HCl
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2245697-84-9
PubChem ID	134160246
InChi Key	ORRMBTUTYKQYQU-UHFFFAOYSA-N
Smiles	O=C(C1=C(C(OCC(NCCOCCOCCOCCN)=O)=CC=C1)C2=O)N2C(C(N3)=O)CCC3=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Thalidomide 4'-oxyacetamide-PEG3-amine

References are publications that support the biological activity of the product.

Salami Waste disposal-An attractive strategy for cancer therapy. Science 2017 PMID: 28302825
Winter Functionalized Cereblon ligand for PROTACs; incorporates an E3 ligase ligand and a linker used in PROTAC technology. Science 2015 PMID: 25999370