ZNL 02-096
Tocris Bioscience, part of Bio-Techne | Catalog # 7240
Potent and selective Wee1 Degrader (PROTAC®)
Key Product Details
Description
Potent and selective Wee1 Degrader (PROTAC®)
Product Description
ZNL 02-096 is a potent and selective Wee1 Degrader (PROTAC®) that comprises the Wee1 inhibitor AZD 1775 joined by a linker to the cereblon-binding ligand Pomalidomide (Cat. No. 6302). ZNL 02-096 selectively degrades Wee1 at submicromolar concentrations, while sparing PLK1, an AZD 1775 secondary target. In MOLT-4 cells in vitro, ZNL 02-096 induces degradation of Wee1, accumulation of DNA damage, arrest of the cell cycle in the G2/M phase and apoptosis. The compound shows antiproliferative effects in a panel of 300 cancer cell lines.Wee1 antibody validated for Western Blot also available: Catalog # NBP1-33506.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Licensing Information
Sold under license from Dana-Farber Cancer Institute.Product Specifications
Molecular Weight
799.89
Formula
C42H45N11O6
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-((3-(4-(4-((2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)propyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
CAS Number
2414418-49-6
PubChem ID
153555373
InChI Key
LZUDSNUROXNVPH-UHFFFAOYSA-N
SMILES
CC(O)(C1=NC(N2N(C(C3=CN=C(N=C23)NC4=CC=C(N5CCN(CC5)CCCNC6=C7C(N(C(C7=CC=C6)=O)C8CCC(NC8=O)=O)=O)C=C4)=O)CC=C)=CC=C1)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.99 | 50 |
Preparing Stock Solutions
for ZNL 02-096
The following data is based on the product molecular weight 799.89
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 2.50 mL | 12.50 mL | 25.00 mL |
| 2.5 mM | 0.50 mL | 2.50 mL | 5.00 mL |
| 5 mM | 0.25 mL | 1.25 mL | 2.50 mL |
| 25 mM | 0.05 mL | 0.25 mL | 0.50 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Li Development and characterization of a Wee1 kinase degrader. Cell Chem.Biol. 2020 PMID: 31735695
Product Specific Notices for ZNL 02-096
For research use only
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