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32 results for "Compounds for Stem Cell Proliferation and Renewal Small Molecules and Peptides" in Products

Compounds for Stem Cell Proliferation and Renewal: Small Molecules and Peptides

Pluripotent Stem Cell Maintenance

Proliferation and self-renewal of stem cells occurs via the division of a cell into two identical daughter cells, resulting in the production of cells identical to the parent. Unlike other cell types, such as muscle or blood cells, stem cells are able to replicate many times. Under the right conditions stem cells can continue to proliferate in culture over many months without differentiation and specialization, yielding millions of cells; this is known as ...

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Selective ROCK inhibitor; inhibits ROCK1 (p160 ROCK) and ROCK2; stem cell freezing (cryopreservation) media component

Alternate Names: y27632,Y-27632 2HCl,ROCK inhibitor,ROCK1 inhibitor
Chemical Name: trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride
Purity: ≥98% (HPLC)
ROCK inhibition by Y-27632 and immunostaining of skeletal myogenic differentiation of MESP1+ mesoderm,
(8)

Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7

Chemical Name: 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide
Purity: ≥99% (HPLC)
dopaminergic neurons derived from hiPSCs using SB 431542
(2)

Y-27632 synthesized to cGMP guidelines

Chemical Name: trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride
Purity: ≥99%
Y-27632 synthesized to cGMP guidelines

SB 431542 synthesized to cGMP guidelines

Chemical Name: 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide
Purity: ≥99%
SB 431542 synthesized to cGMP guidelines

Selective inhibitor of TGF-βRI, ALK4 and ALK7

Chemical Name: 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
Purity: ≥98% (HPLC)
Adult Stem Cell-derived Liver Organoids
(6)

Promotes HSCs expansion; increases HSCs engraftment; also endogenous prostaglandin

Alternate Names: PGE2
Chemical Name: (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1-oic acid
Purity: ≥98% (HPLC)
Promotes HSCs expansion; increases HSCs engraftment; also endogenous prostaglandin

Selective inhibitor of p38 MAPK

Alternate Names: Adezmapimod
Chemical Name: 4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]pyridine
Purity: ≥98% (HPLC)
Selective inhibitor of p38 MAPK

Prototypical PI 3-kinase inhibitor; also inhibits other kinases

Chemical Name: 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one hydrochloride
Purity: ≥99% (HPLC)
Prototypical PI 3-kinase inhibitor; also inhibits other kinases

Sterile-filtered 10 mM solution of Y-27632, selective ROCK inhibitor, pre-dissolved in water

Chemical Name: trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride
Purity: ≥97% (HPLC)
vial of Y-27632 in solution
(2)

Highly potent and selective ROCK 2 inhibitor; improves cell survival after cryogenesis

Chemical Name: (3S)-N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-3,4-dihydro-6-methoxy-2H-1-benzopyran-3-carboxamide dihydrochloride
Purity: ≥98% (HPLC)
Highly potent and selective ROCK 2 inhibitor; improves cell survival after cryogenesis

MEK inhibitor

Chemical Name: 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)
MEK inhibitor

Potent pan-caspase inhibitor

Alternate Names: IDN-6556,PF-03491390
Chemical Name: N-[2-(1,1-Dimethylethyl)phenyl]-2-oxoglycyl-N-[(1S)-1-(carboxymethyl)-2-oxo-3-(2,3,5,6-tetrafluorophenoxy)propyl]-L-alaninamide
Purity: ≥98% (HPLC)
Potent pan-caspase inhibitor

PORCN inhibitor; inhibits Wnt processing and secretion

Chemical Name: N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
Purity: ≥98% (HPLC)
iPSC-derived heart organoids differentiated with IWP 2 and CHIR 99021
(2)

Potent AMPK activator

Chemical Name: 6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile
Purity: ≥98% (HPLC)
Potent AMPK activator

Potent integrin inhibitor (αvβ3/αvβ6); also improves stem cell attachment in 3D cell culture scaffolds

Purity: ≥95% (HPLC)
Potent integrin inhibitor (αVβ3/αVβ5); also improves stem cell attachment in 3D cell culture scaffolds

FGFR1 and -3 inhibitor

Chemical Name: N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea
Purity: ≥98% (HPLC)
FGFR1 and -3 inhibitor

Induces growth and proliferation of pancreatic islet cells, murine totipotent stem cells, GABAergic neurons and hippocampal neurons

Chemical Name: 4-[[6-[(Cyclopropylcarbonyl)amino]-4-pyrimidinyl]oxy]-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzeneacetamide
Purity: ≥98% (HPLC)
Induces growth and proliferation of pancreatic islet cells, murine totipotent stem cells, GABAergic neurons and hippocampal neurons

Potent, selective GSK-3 inhibitor

Chemical Name: 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Purity: ≥98% (HPLC)
Potent, selective GSK-3 inhibitor

Potent GSK-3 inhibitor; also inhibits cdks

Alternate Names: 6BIO
Chemical Name: (2'Z,3'E)-6-Bromoindirubin-3'-oxime
Purity: ≥98% (HPLC)
Potent GSK-3 inhibitor; also inhibits cdks

T3 synthesized to Ancillary Material Grade

Chemical Name: O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine
Purity: ≥98%
TB6666-RMU vial
(2)

Notch signaling pathway activator; enhances the self-renewal capability of NSCs; active in vivo

Chemical Name: 5-(3-Methoxyphenoxy)-N2-[4-(1-methylethyl)phenyl]-2,4-quinazolinediamine hydrochloride
Purity: ≥98% (HPLC)
Notch signaling pathway activator; enhances the self-renewal capability of NSCs; active in vivo

Minimal recognition sequence for integrin binding; potent integrin inhibitor

Purity: ≥95% (HPLC)
Minimal recognition sequence for integrin binding; potent integrin inhibitor

A 83-01 synthesized to Ancillary Material Grade

Chemical Name: 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
Purity: ≥98%
A 83-01 synthesized to Ancillary Material Grade

Potent and selective Lck and Src inhibitor; also inhibits SIK

Alternate Names: KIN112
Chemical Name: 2,6-Dimethylphenyl-N-(2,4-dimethoxyphenyl)-N-[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]carbamate
Purity: ≥98% (HPLC)
Potent and selective Lck and Src inhibitor; also inhibits SIK

Selective PPARγ agonist; antidiabetic agent

Alternate Names: Rezulin
Chemical Name: 5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione
Purity: ≥98% (HPLC)
Selective PPARγ agonist; antidiabetic agent
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