Emricasan
Tocris Bioscience, part of Bio-Techne | Catalog # 7310
Potent pan-caspase inhibitor
Key Product Details
Description
Potent pan-caspase inhibitor
Alternative Names
IDN-6556,PF-03491390
Product Description
Emricasan is a potent caspase inhibitor (IC50 values are 0.3, 0.4, 2, 4, 6, 6 and 20 nM for caspase-9, -1, -3, -6, -7, -8, and -2, respectively). Emricasan is antiapoptotic by inhibiting caspase 8. It also preserves cell viability after infection with several strains of Zika. Emricasan promotes survival of pluripotent stem cells in culture when used in combination with Chroman-1 (Cat. No. 7163), trans-ISRIB (Cat. No. 5284) and Polyamine Supplement x1000 (lyophilized) (Cat. No. 7739), a combination known as CEPT. When used as part of the CEPT cocktail, Emricasan improves survival of differentiated cells following cryopreservation. The compound also reduces hepatic inflammation in an animal model of liver injury. Orally bioavailable.Product Specifications
Molecular Weight
569.51
Formula
C26H27F4N3O7
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[2-(1,1-Dimethylethyl)phenyl]-2-oxoglycyl-N-[(1S)-1-(carboxymethyl)-2-oxo-3-(2,3,5,6-tetrafluorophenoxy)propyl]-L-alaninamide
CAS Number
254750-02-2
PubChem ID
12000240
InChI Key
SCVHJVCATBPIHN-SJCJKPOMSA-N
SMILES
N(C(C(N[C@H](C(N[C@H](C(COC1=C(F)C(F)=CC(F)=C1F)=O)CC(O)=O)=O)C)=O)=O)C2=C(C(C)(C)C)C=CC=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 56.95 | 100 | |
| Ethanol | 28.48 | 50 |
Preparing Stock Solutions
for Emricasan
The following data is based on the product molecular weight 569.51
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.76 mL | 8.78 mL | 17.56 mL |
| 5 mM | 0.35 mL | 1.76 mL | 3.51 mL |
| 10 mM | 0.18 mL | 0.88 mL | 1.76 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.35 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Canbay The caspase inhibitor IDN-6556 attenuates hepatic injury and fibrosis in the bile duct ligated mouse. J.Pharmacol.Exp.Ther. 2004 PMID: 14617689
- Chen A versatile polypharmacology platform promotes cytoprotection and viability of human pluripotent and differentiated cells. Nat.Methods 2021 PMID: 33941937
Product Specific Notices for Emricasan
For research use only
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