WS 6
Tocris Bioscience, part of Bio-Techne | Catalog # 7791
Induces growth and proliferation of pancreatic islet cells, murine totipotent stem cells, GABAergic neurons and hippocampal neurons
Key Product Details
Description
Induces growth and proliferation of pancreatic islet cells, murine totipotent stem cells, GABAergic neurons and hippocampal neurons
Product Description
WS 6 induces growth and proliferation of cultured islet α and β cells in vitro (EC50 = 0.28 μM at β cells). Inhibits growth of FLT3-ITD+ AML and K562 CML cells (IC50 values are <0.24 nM and 40.48 nM, respectively). Reduces blood glucose in an animal model of type 1 diabetes. In combination with TTNPB (Cat. No. 0761) and 1-azakenpaullone, WS 6 induces and maintains murine totipotent stem cells. In an animal model of depression WS 6 induces dendrite complexity, enhances hippocampal neurogenesis, increases GABAergic neurons and GABA expression, and displays antidepressant and anxiolytic activity. WS 6 is predicted to be a receptor tyrosine kinase inhibitor.Product Specifications
Molecular Weight
568.59
Formula
C29H31F3N6O3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-[[6-[(Cyclopropylcarbonyl)amino]-4-pyrimidinyl]oxy]-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzeneacetamide
CAS Number
1421227-53-3
PubChem ID
71566751
InChI Key
FTODTDQFHDJWIQ-UHFFFAOYSA-N
SMILES
O=C(NC1=CC=C(C(=C1)C(F)(F)F)CN2CCN(C)CC2)CC3=CC=C(OC4=NC=NC(=C4)NC(=O)C5CC5)C=C3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 56.86 | 100 | |
| Ethanol | 56.86 | 100 |
Preparing Stock Solutions
for WS 6
The following data is based on the product molecular weight 568.59
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.76 mL | 8.79 mL | 17.59 mL |
| 5 mM | 0.35 mL | 1.76 mL | 3.52 mL |
| 10 mM | 0.18 mL | 0.88 mL | 1.76 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.35 mL |
Calculators
Molarity Calculator
Dilution Calculator
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Background References
References are publications that support the biological activity of the product.
- Bregante Efficacy and synergy of small molecule inhibitors targeting FLT3-ITD+ acute myeloid leukemia. Cancers (Basel) 2021 PMID: 34944800
- Shen Small-molecule inducer of β cell proliferation identified by high-throughput screening. J.Am.Chem.Soc. 2013 PMID: 23330637
- Zhang WS6 induces adult hippocampal neurogenesis in correlation to its antidepressant effect on the alleviation of depressive-like behaviors of rats. Neuroscience 2021 PMID: 34455011
- Menhaji-Klotz and Price Small molecules that promote regenerative repair for pancreatic and cardiovascular health. Bioorg.Med.Chem.Lett. 2015 PMID: 26508547
- Hu Induction of mouse totipotent stem cells by a defined chemical cocktail. Nature 2022 PMID: 35728625
Product Specific Notices for WS 6
For research use only
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