TTNPB

Name: TTNPB
Brand: Tocris Bioscience
SKU: 0761

Catalog # 0761 | Tocris Bioscience a Bio-Techne Brand

Citations (7)

COA / SDS

Retinoic acid analog; RAR agonist

Key Product Details

Description:	Retinoic acid analog; RAR agonist
Alternative Names:	Ro 13-7410
Chemical Name:	4-[(E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	348.48

View Full Technical Details for TTNPB

Technical Data
Citations (7) / Reviews

Biological Activity for TTNPB

TTNPB is an extremely potent analog of retinoic acid, selective for the retinoic acid receptor (RAR) subtype. Enhances reprogramming efficiency in chemically induced pluripotent stem cells (CiPSCs).

Technical Data for TTNPB

M. Wt	348.48
Formula	C₂₄H₂₈O₂
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	71441-28-6
PubChem ID	5289501
InChi Key	FOIVPCKZDPCJJY-JQIJEIRASA-N
Smiles	C\C(=C/C1=CC=C(C=C1)C(O)=O)C1=CC=C2C(=C1)C(C)(C)CCC2(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TTNPB

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	3.48	10

Preparing Stock Solutions for TTNPB

The following data is based on the product molecular weight 348.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.70 mL	143.48 mL	286.96 mL
0.5 mM	5.74 mL	28.70 mL	57.39 mL
1 mM	2.87 mL	14.35 mL	28.70 mL
5 mM	0.57 mL	2.87 mL	5.74 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for TTNPB

References are publications that support the biological activity of the product.

Hou Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science 2013 PMID: 23868920
Minucci Retinoid X receptor-selective ligands produce malformations in Xenopus embryos. Proc.Natl.Acad.Sci.U.S.A. 1996 PMID: 8700839
Loeliger Arotinoids, a new class of highly active retinoids. Eur.J.Med.Chem.-Chim.Ther.

Citations for TTNPB (7)

Showing 1 - 7 of 7 citations Showing All

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for TTNPB include:

Cordeiro et al. (2019) Interplay of Protein Disorder in Retinoic Acid Receptor Heterodimer and Its Corepressor Regulates Gene Expression. Structure. 2019;
PMID: 31178221
Wang et al. (2017) Retinoic acid inhibits white adipogenesis by disrupting GADD45A-mediated Zfp423 DNA demethylation. J Mol Cell Biol. 9:338
PMID: 28992291
Chronopoulos et al. (2016) ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion Nature Communications. 7:12630
PMID: 27600527
Francipane and Lagasse (2015) The lymph node as a new site for kidney organogenesis. Stem Cells Transl Med. 4:295
PMID: 25646529
Zhang et al. (2015) Small Molecules Efficiently Reprogram Human Astroglial Cells into Functional Neurons. Cell Stem Cell. 17:735
PMID: 26481520
Thomas and Henry (2014) Retinoic acid regulation by CYP26 in vertebrate lens regeneration. Br J Pharmacol. 386:291
PMID: 24384390
Tay et al. (2010) A comparison of the roles of peroxisome proliferator-activated receptor and retinoic acid receptor on CYP26 regulation. Mol Pharmacol. 77:218
PMID: 19884280

There are no citations that match your criteria.