TTNPB

Name: TTNPB
Brand: Tocris Bioscience
SKU: 0761

Tocris Bioscience, part of Bio-Techne | Catalog # 0761

Citations (55)

COA / SDS

Retinoic acid analog; RAR agonist

Key Product Details

Description:	Retinoic acid analog; RAR agonist
Alternative Names:	Ro 13-7410
Chemical Name:	4-[(E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	348.48

View Full Technical Details for TTNPB

Technical Data
Citations

Biological Activity for TTNPB

TTNPB is an extremely potent analog of retinoic acid, selective for the retinoic acid receptor (RAR) subtype. Enhances reprogramming efficiency in chemically induced pluripotent stem cells (CiPSCs).

Technical Data for TTNPB

M. Wt	348.48
Formula	C₂₄H₂₈O₂
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	71441-28-6
PubChem ID	5289501
InChi Key	FOIVPCKZDPCJJY-JQIJEIRASA-N
Smiles	C\C(=C/C1=CC=C(C=C1)C(O)=O)C1=CC=C2C(=C1)C(C)(C)CCC2(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TTNPB

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	3.48	10

Preparing Stock Solutions for TTNPB

The following data is based on the product molecular weight 348.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.70 mL	143.48 mL	286.96 mL
0.5 mM	5.74 mL	28.70 mL	57.39 mL
1 mM	2.87 mL	14.35 mL	28.70 mL
5 mM	0.57 mL	2.87 mL	5.74 mL

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Reconstitution Calculator

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References for TTNPB

References are publications that support the biological activity of the product.

Loeliger Arotinoids, a new class of highly active retinoids. Eur.J.Med.Chem.-Chim.Ther.
Hou Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science 2013 PMID: 23868920
Minucci Retinoid X receptor-selective ligands produce malformations in Xenopus embryos. Proc.Natl.Acad.Sci.U.S.A. 1996 PMID: 8700839