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12 results for "S1P1/EDG-1 Small Molecules and Peptides" in Products

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S1P1/EDG-1 Small Molecules and Peptides

EDG molecules are G protein-coupled receptors that bind plasma lysophospholipids. The EDG family consists of two subfamilies; the S1P (sphingosine-1-phosphate) subfamily consisting of EDG-1, 3, 5, 6, and 8, and the LPA (lysophosphatidic acid) subfamily that contains EDG-2, 4 and 7. Each receptor is the product of a distinct gene. The S1P family regulates essential cellular processes such as proliferation, migration, cytoskeletal organization, and differentiation.

Sphingosine-1-phosphate

Catalog #: 1370

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Endogenous agonist at S1P1-5

Chemical Name:

(E)-D-erythro-2-amino-1-(dihydrogenphosphate)-4-octadecene-1,3-diol

Purity:

≥98%

CS 2100

Catalog #: 4543

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Selective S1P1 agonist

Chemical Name:

1-[[4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylic acid

Purity:

≥97%

FTY 720

Catalog #: 6176

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Potent S1P receptor agonist; also immunosuppressant

Alternate Names:

Fingolimod,Gilenya

Chemical Name:

2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride

Purity:

≥98%

SEW 2871

Catalog #: 2284

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Cell-permeable, selective S1P1 receptor agonist

Chemical Name:

5-[4-Phenyl-5-(trifluoromethyl)thiophen-2-yl]-3-[3-(trifluoromethyl)phenyl]1,2,4-oxadiazole

Purity:

≥98%

CYM 5442 hydrochloride

Catalog #: 3601

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Selective S1P1 receptor agonist

Chemical Name:

2-(4-(5-(3,4-Diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino) ethanol hydrochloride

Purity:

≥98%

W146

Catalog #: 3602

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Potent and selective S1P1 receptor antagonist

Alternate Names:

ML 056

Chemical Name:

[(3R)-3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid

Purity:

≥98%

VPC 23019

Catalog #: 4195

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S1P1 and S1P3 antagonist

Chemical Name:

2-Amino-N-(3-octylphenyl)-3-(phosphonooxy)-propanamaide

Purity:

≥95%

RP 001 hydrochloride

Catalog #: 4289

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Potent S1P1 agonist

Chemical Name:

N-[4-[5-[3-Cyano-4-(1-methylethoxy)phenyl]-1,2,4-oxadiazol-3-yl]-2,3-dihydro-1H-inden-1-yl]-β-alanine hydrochloride

Purity:

≥98%

Ex 26

Catalog #: 5833

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Potent and selective S1P1 receptor antagonist

Chemical Name:

1-[[[5'-[[1-(4-Chloro-3-methylphenyl)ethyl]amino]-2'-fluoro-3,5-dimethyl[1,1'-biphenyl]-4-yl]carbonyl]amino]-cyclopropanecarboxylic acid

Purity:

≥98%

Ex 26

Catalog #: 5833

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Potent and selective S1P1 receptor antagonist

Chemical Name:

1-[[[5'-[[1-(4-Chloro-3-methylphenyl)ethyl]amino]-2'-fluoro-3,5-dimethyl[1,1'-biphenyl]-4-yl]carbonyl]amino]-cyclopropanecarboxylic acid

Purity:

≥98%

GSK 2018682

Catalog #: 6709

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S1P1 and S1P5 agonist

Chemical Name:

4-[5-[5-Chloro-6-(1-methylethoxy)-3-pyridinyl]-1,2,4-oxadiazol-3-yl]-1H-indole-1-butanoic acid

Purity:

≥98%

GSK 2018682

Catalog #: 6709

Product Documents

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S1P1 and S1P5 agonist

Chemical Name:

4-[5-[5-Chloro-6-(1-methylethoxy)-3-pyridinyl]-1,2,4-oxadiazol-3-yl]-1H-indole-1-butanoic acid

Purity:

≥98%

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