Ex 26

Tocris Bioscience, part of Bio-Techne | Catalog # 5833

Citations (15)

COA / SDS

Potent and selective S1P1 receptor antagonist

100% Guarantee

Product Description
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent and selective S1P1 receptor antagonist

View all Sphingosine-1-phosphate Receptor Antagonists »

Product Description

Ex 26 is a potent and selective S1P₁ receptor antagonist (IC₅₀ = 0.93 nM). Exhibits > 3,000-fold selectivity for S1P₁ over S1P₂, S1P₃, S1P₄ and S1P₅. Induces lymphocyte sequestration in peripheral lymph nodes and upregulates S1P₁ receptor expression. Reduces disease severity in mice with EAE. Increases IFN-α production in stimulated dendritic cells in vivo.

Product Specifications

Molecular Weight

494.98

Formula

C₂₈H₂₈ClFN₂O₃

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

1-[[[5'-[[1-(4-Chloro-3-methylphenyl)ethyl]amino]-2'-fluoro-3,5-dimethyl[1,1'-biphenyl]-4-yl]carbonyl]amino]-cyclopropanecarboxylic acid

CAS Number

1233332-37-0

PubChem ID

59393740

InChI Key

YVHNBORUVLWCKF-UHFFFAOYSA-N

SMILES

CC(C1=CC(C)=C(C=C1)Cl)NC2=CC=C(C(C3=CC(C)=C(C(C)=C3)C(NC4(C(O)=O)CC4)=O)=C2)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	49.5	100
	Ethanol	49.5	100

Preparing Stock Solutions for Ex 26

The following data is based on the product molecular weight 494.98

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.02 mL	10.10 mL	20.20 mL
5 mM	0.40 mL	2.02 mL	4.04 mL
10 mM	0.20 mL	1.01 mL	2.02 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

Background References

References are publications that support the biological activity of the product.

Cahalan Sphingosine 1-phosphate receptor 1 (S1P₁) upregulation and amelioration of experimental autoimmune encephalomyelitis by an S1P₁ antagonist. Mol.Pharmacol. 2013 PMID: 23204443
Kleinwort S1P signalling differentially affects migration of peritoneal B cell populations in vitro and influences the production of intestinal IgA in vivo. Int.J.Mol.Sci. 2018 PMID: 29382132
Teijaro S1PR₁-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell IF.-a autoamplification. Proc.Natl.Acad.Sci.U.S.A. 2016 PMID: 26787880