GSK 2018682
Tocris Bioscience, part of Bio-Techne | Catalog # 6709
S1P1 and S1P5 agonist
Key Product Details
Description
S1P1 and S1P5 agonist
Product Description
GSK 2018682 is a sphingosine-1-phosphate receptor 1 (S1P1) and 5 (S1P5) agonist.Product Specifications
Molecular Weight
440.88
Formula
C22H21ClN4O4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-[5-[5-Chloro-6-(1-methylethoxy)-3-pyridinyl]-1,2,4-oxadiazol-3-yl]-1H-indole-1-butanoic acid
CAS Number
1034688-30-6
PubChem ID
24988201
InChI Key
NFIGDBFIDKDNIG-UHFFFAOYSA-N
SMILES
CC(OC1=NC=C(C2=NC(C3=C4C=CN(C4=CC=C3)CCCC(O)=O)=NO2)C=C1Cl)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.09 | 100 |
Preparing Stock Solutions
for GSK 2018682
The following data is based on the product molecular weight 440.88
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.27 mL | 11.34 mL | 22.68 mL |
| 5 mM | 0.45 mL | 2.27 mL | 4.54 mL |
| 10 mM | 0.23 mL | 1.13 mL | 2.27 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.45 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Subei and Cohen Sphingosine 1-phosphate receptor modulators in multiple sclerosis. CNS.Drugs. 2015 PMID: 26239599
- Bigaud Second generation S1P pathway modulators: research strategies and clinical developments. Biochim.Biophys.Acta. 2014 PMID: 24239768
Product Specific Notices for GSK 2018682
For research use only
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