GSK 2018682

Name: GSK 2018682
Brand: Tocris Bioscience
SKU: 6709

Tocris Bioscience, part of Bio-Techne | Catalog # 6709

COA / SDS

S1P1 and S1P5 agonist

Key Product Details

Description:	S1P₁ and S1P₅ agonist
Chemical Name:	4-[5-[5-Chloro-6-(1-methylethoxy)-3-pyridinyl]-1,2,4-oxadiazol-3-yl]-1H-indole-1-butanoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	440.88

View Full Technical Details for GSK 2018682

Technical Data
Citations

Biological Activity for GSK 2018682

GSK 2018682 is a sphingosine-1-phosphate receptor 1 (S1P₁) and 5 (S1P₅) agonist.

Compound Libraries for GSK 2018682

GSK 2018682 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for GSK 2018682

M. Wt	440.88
Formula	C₂₂H₂₁ClN₄O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1034688-30-6
PubChem ID	24988201
InChi Key	NFIGDBFIDKDNIG-UHFFFAOYSA-N
Smiles	CC(OC1=NC=C(C2=NC(C3=C4C=CN(C4=CC=C3)CCCC(O)=O)=NO2)C=C1Cl)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GSK 2018682

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	44.09	100

Preparing Stock Solutions for GSK 2018682

The following data is based on the product molecular weight 440.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.27 mL	11.34 mL	22.68 mL
5 mM	0.45 mL	2.27 mL	4.54 mL
10 mM	0.23 mL	1.13 mL	2.27 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

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References for GSK 2018682

References are publications that support the biological activity of the product.

Subei and Cohen Sphingosine 1-phosphate receptor modulators in multiple sclerosis. CNS.Drugs. 2015 PMID: 26239599
Bigaud Second generation S1P pathway modulators: research strategies and clinical developments. Biochim.Biophys.Acta. 2014 PMID: 24239768