RP 001 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 4289
Potent S1P1 agonist
Key Product Details
Description
Potent S1P1 agonist
Product Description
RP 001 hydrochloride is a potent agonist of S1P1 receptors (EC50 = 9 pM). Induces internalization and polyubiquitination of S1P1 in vitro. Selective for S1P1 over S1P2 - S1P4.Product Specifications
Molecular Weight
468.93
Formula
C24H24N4O4.HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[4-[5-[3-Cyano-4-(1-methylethoxy)phenyl]-1,2,4-oxadiazol-3-yl]-2,3-dihydro-1H-inden-1-yl]-β-alanine hydrochloride
CAS Number
1781880-34-9
PubChem ID
90488927
InChI Key
ZHPGSGYEFGEZAL-UHFFFAOYSA-N
SMILES
CC(C)OC1=C(C#N)C=C(C2=NC(C3=C(CCC4NCCC(O)=O)C4=CC=C3)=NO2)C=C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.25 | 100 |
Preparing Stock Solutions
for RP 001 hydrochloride
The following data is based on the product molecular weight 468.93
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.13 mL | 10.66 mL | 21.33 mL |
| 5 mM | 0.43 mL | 2.13 mL | 4.27 mL |
| 10 mM | 0.21 mL | 1.07 mL | 2.13 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.43 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Cahalan Actions of a picomolar short-acting S1P1 agonist in S1P1-eGFP knock-in mice. Nat.Chem.Biol. 2011 PMID: 21445057
Product Specific Notices for RP 001 hydrochloride
For research use only
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