CYM 5442 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 3601
Selective S1P1 receptor agonist
Key Product Details
Description
Selective S1P1 receptor agonist
Product Description
CYM 5442 hydrochloride is a potent and selective S1P1 agonist in vitro (EC50 = 1.35 nM). Activates S1P1-mediated p42/p44 MAPK phosphorylation in CHO-K1 cells transfected with S1P1. Induces acute lymphopenia in mice. Brain penetrant.Product Specifications
Molecular Weight
445.94
Formula
C23H27N3O4.HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-(4-(5-(3,4-Diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino) ethanol hydrochloride
CAS Number
1783987-80-3
PubChem ID
90488865
InChI Key
KMZLVDAVGXYZDA-UHFFFAOYSA-N
SMILES
OCCNC3CCC(C3=CC=C4)=C4C1=NOC(C2=CC(OCC)=C(OCC)C=C2)=N1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.59 | 100 |
Preparing Stock Solutions
for CYM 5442 hydrochloride
The following data is based on the product molecular weight 445.94
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.24 mL | 11.21 mL | 22.42 mL |
| 5 mM | 0.45 mL | 2.24 mL | 4.48 mL |
| 10 mM | 0.22 mL | 1.12 mL | 2.24 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.45 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Gonzalez-Cabrera Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions Mol.Pharmacol. 2008 PMID: 18708635
Product Specific Notices for CYM 5442 hydrochloride
For research use only
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