SEW 2871

Name: SEW 2871
Brand: Tocris Bioscience
SKU: 2284

Tocris Bioscience, part of Bio-Techne | Catalog # 2284

Citations (36)

COA / SDS

Cell-permeable, selective S1P1 receptor agonist

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Product Description
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Cell-permeable, selective S1P1 receptor agonist

View all Sphingosine-1-phosphate Receptor Agonists »

Product Description

SEW 2871 is a novel, potent and selective sphingosine-1-phosphate 1 (S1P₁) receptor agonist. Activates S1P₁ receptor with an EC₅₀ of 13 nM, but does not activate S1P₂, S1P₃, S1P₄ or S1P₅ receptors at concentrations up to 10 μM. Cell-permeable and active in vivo.

Product Specifications

Molecular Weight

440.36

Formula

C₂₀H₁₀F₆N₂OS

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

5-[4-Phenyl-5-(trifluoromethyl)thiophen-2-yl]-3-[3-(trifluoromethyl)phenyl]1,2,4-oxadiazole

CAS Number

256414-75-2

PubChem ID

4077460

InChI Key

OYMNPJXKQVTQTR-UHFFFAOYSA-N

SMILES

FC(F)(F)C1=C(C=C(S1)C1=NC(=NO1)C1=CC(=CC=C1)C(F)(F)F)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	8.81	20
	Ethanol	8.81	20

Preparing Stock Solutions for SEW 2871

The following data is based on the product molecular weight 440.36

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	11.35 mL	56.77 mL	113.54 mL
1 mM	2.27 mL	11.35 mL	22.71 mL
2 mM	1.14 mL	5.68 mL	11.35 mL
10 mM	0.23 mL	1.14 mL	2.27 mL

Calculators

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

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Reconstitution Calculator

Background References

References are publications that support the biological activity of the product.

Sanna Sphingosine 1-phosphate (S1P) receptor subtypes S1P₁ and S1P₃, respectively, regulate lymphocyte recirculation and heart rate. J.Biol.Chem. 2004 PMID: 14732717
Bolick Sphingosine-1-phosphate prevents tumor necrosis factor-α-mediated monocyte adhesion to aortic endothelium in mice. Arterioscler.Thromb.Vasc.Biol. 2005 PMID: 15761190
Hale A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists. J.Med.Chem. 2004 PMID: 15615513