CS 2100

Tocris Bioscience, part of Bio-Techne | Catalog # 4543

COA / SDS

Selective S1P1 agonist

Key Product Details

Description:	Selective S1P₁ agonist
Chemical Name:	1-[[4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylic acid
Purity:	≥97% (HPLC)
Molecular Weight:	461.53

View Full Technical Details for CS 2100

Technical Data
Citations

Biological Activity for CS 2100

CS 2100 is a sphingosine-1-phosphate receptor 1 (S1P₁) agonist (EC₅₀ = 4.0 nM). Exhibits 5000-fold selectivity for human S1P₁ over S1P₃. Displays efficacy in a rat adjuvant-induced arthritis model.

Technical Data for CS 2100

M. Wt	461.53
Formula	C₂₅H₂₃N₃O₄S
Storage	Store at +4°C
Purity	≥97% (HPLC)
CAS Number	913827-99-3
PubChem ID	11977938
InChi Key	DWVJASHDNJMDNH-UHFFFAOYSA-N
Smiles	CCC1=C(C2=NOC(C4=CC=C(OC5=CC=CC=C5)C=C4)=N2)SC(CN3CC(C(O)=O)C3)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CS 2100

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	2.31	5 with gentle warming

Preparing Stock Solutions for CS 2100

The following data is based on the product molecular weight 461.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	43.33 mL	216.67 mL	433.34 mL
0.25 mM	8.67 mL	43.33 mL	86.67 mL
0.5 mM	4.33 mL	21.67 mL	43.33 mL
2.5 mM	0.87 mL	4.33 mL	8.67 mL

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Reconstitution Calculator

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References for CS 2100

References are publications that support the biological activity of the product.

Nakamura Discovery of CS-2100, a potent, orally active and S1P₃-sparing S1P₁ agonist. Bioorg.Med.Chem.Lett. 2012 PMID: 22264485
Nakamura Synthesis and evaluation of CS-2100, a potent, orally active and S1P₃-sparing S1P₁ agonist. Eur.J.Med.Chem. 2012 PMID: 22405291