49 results for "Organoid Compounds" in Products

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Organoid Compounds

Y-27632 dihydrochloride
Catalog #: 1254
(19)
Citations (1869)
Product Documents
Images (8)

Selective ROCK inhibitor; inhibits ROCK1 (p160 ROCK) and ROCK2; stem cell freezing (cryopreservation) media component

GMP Version Available: TB1254-GMP
GMP
Alternate Names:
y27632,Y-27632 2HCl,ROCK inhibitor,ROCK1 inhibitor
Chemical Name:
trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride
Purity:
≥98%
ROCK inhibition by Y-27632 and immunostaining of skeletal myogenic differentiation of MESP1+ mesoderm,
(8)
Catalog #
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1254/50
1254/10
1254/1
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SB 431542
Catalog #: 1614
(13)
Citations (2529)
Product Documents
Images (2)

Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7

GMP Version Available: TB1614-GMP
GMP
Chemical Name:
4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide
Purity:
≥99%
dopaminergic neurons derived from hiPSCs using SB 431542
(2)
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1614/1
1614/10
1614/50
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CHIR 99021
Catalog #: 4423
(19)
Citations (2270)
Product Documents
Images (2)

Highly selective GSK-3 inhibitor; acts as Wnt activator

GMP Version Available: TB4423-GMP
GMP
Alternate Names:
CHIR99021,CT99021
Chemical Name:
6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile
Purity:
≥98%
Cardiomyocyte derived from human induced pluripotent stem cells (hiPSCs) using CHIR 99021.
(2)
Catalog #
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4423/50
4423/10
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Prostaglandin E2
Catalog #: 2296
(2)
Citations (299)
Product Documents
Images (1)

Promotes HSCs expansion; increases HSCs engraftment; also endogenous prostaglandin

Alternate Names:
PGE2
Chemical Name:
(5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1-oic acid
Purity:
≥98%
Promotes HSCs expansion; increases HSCs engraftment; also endogenous prostaglandin
Catalog #
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2296/10
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Forskolin
Catalog #: 1099
(6)
Citations (944)
Product Documents
Images (2)

Adenylyl cyclase activator

Alternate Names:
Coleonol,Colforsin
Chemical Name:
(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one
Purity:
≥98%
Adult Stem Cell-derived Liver Organoids
(2)
Catalog #
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1099/50
1099/10
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LDN 193189 dihydrochloride
Catalog #: 6053
(3)
Citations (156)
Product Documents
Images (2)

Potent and selective ALK2 and ALK3 inhibitor; inhibits BMP4 signaling; promotes neural induction of hPSCs

GMP Version Available: TB6053-GMP
GMP
Alternate Names:
LDN 193189 2HCl
Chemical Name:
4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
Purity:
≥98%
Application of LDN 193189 in motor neurons differentiated from iPSCs
(2)
Catalog #
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6053/50
6053/10
6053/1
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Dorsomorphin dihydrochloride
Catalog #: 3093
(3)
Citations (321)
Product Documents
Images (1)

Potent AMPK inhibitor; also BMP type I receptor inhibitor

Alternate Names:
Compound C,BML-275
Chemical Name:
6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine dihydrochloride
Purity:
≥98%
Potent AMPK inhibitor; also BMP type I receptor inhibitor
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3093/10
3093/50
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A 83-01
Catalog #: 2939
(12)
Citations (1154)
Product Documents
Images (6)

Selective inhibitor of TGF-βRI, ALK4 and ALK7

Chemical Name:
3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
Purity:
≥98%
Adult Stem Cell-derived Liver Organoids
(6)
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2939/10
2939/50
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IWP 2
Catalog #: 3533
(3)
Citations (547)
Product Documents
Images (2)

PORCN inhibitor; inhibits Wnt processing and secretion

Chemical Name:
N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
Purity:
≥98%
iPSC-derived heart organoids differentiated with IWP 2 and CHIR 99021
(2)
Catalog #
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3533/10
3533/50
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Heparin sodium salt
Catalog #: 2812
(2)
Citations (31)
Product Documents
Images (1)

Anticoagulant

Heparin sodium salt | CAS No. 9041-08-1 | Anticoagulant
Catalog #
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2812/100
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Staurosporine
Catalog #: 1285
(1)
Citations (150)
Product Documents
Images (2)

Non-selective protein kinase inhibitor

Alternate Names:
AM-2282
Chemical Name:
[9S-(9α,10β,11β,13α)]-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
Purity:
≥98%
(2)
Catalog #
Availability
Size / Price
Qty
1285/100U
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DAPT
Catalog #: 2634
(6)
Citations (561)
Product Documents
Images (2)

γ-secretase inhibitor; induces neuronal differentiation; blocks Notch signaling

Chemical Name:
(2S)-N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine 1,1-dimethylethyl ester
Purity:
≥99%
Using DAPT to differentiate hiPSCs into dopaminergic neurons
(2)
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2634/10
2634/50
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BDNF (human)
Catalog #: 2837
(2)
Citations (10)
Product Documents
Images (2)

Activates TrkB and p75 receptors

Purity:
≥95%
BDNF vial product image
(2)
Catalog #
Availability
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Qty
2837/10U
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PD 0325901
Catalog #: 4192
(8)
Citations (388)
Product Documents
Images (1)

Potent inhibitor of MEK1/2

Alternate Names:
PD325901
Chemical Name:
N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
Purity:
≥99%
Potent inhibitor of MEK1/2
Catalog #
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4192/50
4192/10
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Dexamethasone
Catalog #: 1126
(2)
Citations (115)
Product Documents
Images (1)

Anti-inflammatory glucocorticoid

Chemical Name:
(11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methyl-pregna-1,4-diene-3,20-dione
Purity:
≥98%
Anti-inflammatory glucocorticoid
Catalog #
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1126/100
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SB 202190
Catalog #: 1264
(2)
Citations (375)
Product Documents
Images (4)

Potent, selective inhibitor of p38 MAPK

Chemical Name:
4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol
Purity:
≥99%
iPSC-derived Human Intestinal Organoid
(4)
Catalog #
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1264/10
1264/50
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endo-IWR 1
Catalog #: 3532
Citations (71)
Product Documents
Images (1)

Wnt/β-catenin signaling inhibitor; axin stabilizer

Chemical Name:
rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide
Purity:
≥98%
Wnt/β-catenin signaling inhibitor; axin stabilizer
Catalog #
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3532/10
3532/50
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Gastrin I (human)
Catalog #: 3006
(1)
Citations (96)
Product Documents
Images (1)

Selective CCK2 agonist

Purity:
≥95%
Selective CCK2 agonist
Catalog #
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3006/1
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Compound E
Catalog #: 6476
Citations (32)
Product Documents
Images (1)

γ-secretase inhibitor; induces neuronal differentiation

Alternate Names:
γ-Secretase Inhibitor XXI
Chemical Name:
N-[(1S)-2-[[(3S)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide
Purity:
≥98%
γ-secretase inhibitor; induces neuronal differentiation
Catalog #
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6476/1
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Retinoic acid
Catalog #: 0695
Citations (226)
Product Documents
Images (2)

Endogenous retinoic acid receptor agonist

Alternate Names:
Tretinoin,ATRA
Chemical Name:
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2E,4E,6E,8E,-nonatetraenoic acid
Purity:
≥98%
iPSC differentiation with retinoic acid
(2)
Catalog #
Availability
Size / Price
Qty
0695/50
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XAV 939
Catalog #: 3748
(1)
Citations (410)
Product Documents
Images (1)

Potent tankyrase inhibitor

GMP Version Available: TB3748-GMP
GMP
Alternate Names:
XAV939 Wnt Signaling Inhibitor
Chemical Name:
3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one
Purity:
≥98%
Potent tankyrase inhibitor
Catalog #
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3748/10
3748/50
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Iressa
Catalog #: 3000
Citations (369)
Product Documents
Images (1)

Orally active, selective EGFR inhibitor

Alternate Names:
Gefitinib,ZD 1839
Chemical Name:
N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine
Purity:
≥98%
Orally active, selective EGFR inhibitor
Catalog #
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3000/10
3000/50
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Wnt-C59
Catalog #: 5148
(2)
Citations (167)
Product Documents
Images (1)

Highly potent PORCN inhibitor

Chemical Name:
4-(2-Methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]benzeneacetamide
Purity:
≥99%
Highly potent PORCN inhibitor
Catalog #
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5148/10
5148/50
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Chroman 1
Catalog #: 7163
Citations (34)
Product Documents
Images (1)

Highly potent and selective ROCK 2 inhibitor; improves cell survival after cryogenesis

Chemical Name:
(3S)-N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-3,4-dihydro-6-methoxy-2H-1-benzopyran-3-carboxamide dihydrochloride
Purity:
≥98%
Highly potent and selective ROCK 2 inhibitor; improves cell survival after cryogenesis
Catalog #
Availability
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7163/50
7163/10
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SANT-1
Catalog #: 1974
Citations (68)
Product Documents
Images (1)

Inhibitor of hedgehog (Hh) signaling; antagonizes smoothened activity

Chemical Name:
N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-1-piperazinamine
Purity:
≥98%
Inhibitor of hedgehog (Hh) signaling; antagonizes smoothened activity
Catalog #
Availability
Size / Price
Qty
1974/10
1974/50
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