Nicotinic Acetylcholine R alpha 7/CHRNA7: Small Molecules and Peptides
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. nAChR alpha 7/CHRNA7 forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once nAChR alpha 7/CHRNA7 binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
16 results for "Nicotinic Acetylcholine R alpha 7/CHRNA7 Small Molecules and Peptides" in Products
16 results for "Nicotinic Acetylcholine R alpha 7/CHRNA7 Small Molecules and Peptides" in Products
Nicotinic Acetylcholine R alpha 7/CHRNA7: Small Molecules and Peptides
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. nAChR alpha 7/CHRNA7 forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once nAChR alpha 7/CHRNA7 binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Selective α7 nAChR agonist
| Chemical Name: | N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide |
| Purity: | ≥98% (HPLC) |
Selective α7 neuronal nAChR antagonist
| Alternate Names: | MLA |
| Chemical Name: | [1α,4(S),6β,14α,16β]-20-Ethyl-1,6,14,16-tetramethoxy-4-[[[2-(3-methyl-2,5-dioxo-1-pyrrolidinyl)benzoyl]oxy]methyl]aconitane-7,8-diol citrate |
| Purity: | ≥95% (HPLC) |
Positive allosteric modulator of α7 nAChRs; active in vivo
| Chemical Name: | N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-urea |
| Purity: | ≥98% (HPLC) |
Selective α7 nAChR agonist
| Chemical Name: | N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-2,3-dihydro-1,4-benzodioxin-6-carboxamide fumarate |
| Purity: | ≥98% (HPLC) |
Positive allosteric modulator of α7 nAChRs; active in vivo
| Chemical Name: | N-(5-Chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]urea |
| Purity: | ≥98% (HPLC) |
Broad spectrum glutamatergic antagonist
| Chemical Name: | 4-Hydroxyquinoline-2-carboxylic acid |
| Purity: | ≥98% (HPLC) |
Potent and selective α7 nAChR agonist
| Chemical Name: | N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent α4β4, α4β2 and α7 nAChR agonist
| Chemical Name: | (1R,5S)-9-Bromo-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one |
| Purity: | ≥98% (HPLC) |
α7 nAChR partial agonist
| Chemical Name: | 2-[2-(4-Bromophenyl)-2-oxoethyl]-1-methylpyridinium iodide |
| Purity: | ≥98% (HPLC) |
Selective α7 nAChR partial agonist
| Chemical Name: | 4-Bromophenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate hydrochloride |
| Purity: | ≥98% (HPLC) |
α7 nAChR partial agonist
| Chemical Name: | Octahydro-2-methyl-5-(6-phenyl-3-pyridazinyl)-pyrrolo[3,4-c]pyrrole |
| Purity: | ≥98% (HPLC) |
Potent 5-HT3 antagonist; also α7 nAChR partial agonist
| Alternate Names: | Novaban,ICS 205930 |
| Chemical Name: | (3-endo)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 1H-indole-3-carboxylic acid ester monohydrochloride |
| Purity: | ≥98% (HPLC) |
Positive allosteric modulator of α7 nAChRs
| Alternate Names: | XY 4083 |
| Chemical Name: | [N-(4-Chlorophenyl)]-α-[(4-chlorophenyl)-aminomethylene]-3-methyl-5-isoxazoleacetamide |
Allosteric potentiator of α7, α4β2 and α4β4 nAChRs
| Chemical Name: | [2-[(4-Fluorophenyl)amino]-4-methyl-5-thiazolyl]-3-thienylmethanone |
| Purity: | ≥98% (HPLC) |
Positive allosteric modulator of α7 nAChRs; analgesic
| Alternate Names: | (-)-(S)-B 973B |
| Chemical Name: | 3,4-Difluoro-N-[(1S)-1-[6-[4-(2-pyridinyl)-1-piperazinyl]-2-pyrazinyl]ethyl]benzenepropanamide |
| Purity: | ≥98% (HPLC) |
Positive allosteric modulator of α7 nAChRs
| Chemical Name: | 4-[5-(4-Chlorophenyl)-2-methyl-3-(1-oxopropyl)-1H-pyrrol-1-yl]benzenesulfonamide |
| Purity: | ≥97% (HPLC) |
