A 867744
Tocris Bioscience, part of Bio-Techne | Catalog # 4571
Positive allosteric modulator of α7 nAChRs
Key Product Details
Description
Positive allosteric modulator of α7 nAChRs
Product Description
A 867744 is a positive allosteric modulator of α7 nAChRs (IC50 values are 0.98 and 1.12 μM for human and rat α7 receptor ACh-evoked currents respectively, in X. laevis oocytes). Displays no activity at 5-HT3A, α3β4 or α4β2 nAChRs. Brain penetrant.Product Specifications
Molecular Weight
402.89
Formula
C20H19ClN2O3S
Storage
Store at +4°C
Purity
≥97% (HPLC)
Chemical Name
4-[5-(4-Chlorophenyl)-2-methyl-3-(1-oxopropyl)-1H-pyrrol-1-yl]benzenesulfonamide
CAS Number
1000279-69-5
PubChem ID
23642319
InChI Key
ABACVOXFUHDKNZ-UHFFFAOYSA-N
SMILES
O=C(CC)C1=C(C)N(C3=CC=C(S(N)(=O)=O)C=C3)C(C2=CC=C(Cl)C=C2)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.29 | 100 | |
| Ethanol | 4.03 | 10 with gentle warming |
Preparing Stock Solutions
for A 867744
The following data is based on the product molecular weight 402.89
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.48 mL | 12.41 mL | 24.82 mL |
| 5 mM | 0.50 mL | 2.48 mL | 4.96 mL |
| 10 mM | 0.25 mL | 1.24 mL | 2.48 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.50 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Faghih Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the α7 nicotinic acetylcholine receptor. J.Med.Chem. 2009 PMID: 19419141
- Malysz In vitro pharmacological characterization of a novel allosteric modulator of α 7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), exhibiting J.Pharmacol.Exp.Ther. 2009 PMID: 19389923
Product Specific Notices for A 867744
For research use only
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