S 24795
Tocris Bioscience, part of Bio-Techne | Catalog # 3518
α7 nAChR partial agonist
Key Product Details
Description
α7 nAChR partial agonist
Product Description
S 24795 is a partial agonist of α7 nAChR. Improves mnemonic function in aged mice for the treatment of aging-related memory disturbances. Displays more efficient memory-enhancing effects than memantine (Cat. No. 0773) in Alzheimer's disease mouse models.Product Specifications
Molecular Weight
418.07
Formula
C14H13BrINO
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2-[2-(4-Bromophenyl)-2-oxoethyl]-1-methylpyridinium iodide
CAS Number
304679-75-2
PubChem ID
9888248
InChI Key
LERUHBBUGAOYOD-UHFFFAOYSA-M
SMILES
BrC1=CC=C(C(CC2=[N+](C)C=CC=C2)=O)C=C1.[I-]
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 4.18 | 10 with gentle warming | |
| DMSO | 41.81 | 100 |
Preparing Stock Solutions
for S 24795
The following data is based on the product molecular weight 418.07
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.39 mL | 11.96 mL | 23.92 mL |
| 5 mM | 0.48 mL | 2.39 mL | 4.78 mL |
| 10 mM | 0.24 mL | 1.20 mL | 2.39 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Marighetto Comparative effects of the α7 nicotinic partial agonist, S 24795, and the cholinesterase inhibitor, donepezil, against aging-related deficits in declarative and working memory in mice. Psychopharmacology. 2008 PMID: 18265960
- Beracochea Improvement of contextual memory by S 24795 in aged mice: comparison with Mem.. Psychopharmacology 2008 PMID: 18034231
- Lagostena The partial α7 nicotine acetylcholine receptor agonist S 24795 enhances long-term potentiation at CA3-CA1 synapses in the adult mouse hippocampus. Neuropharmacology 2008 PMID: 18187166
Product Specific Notices for S 24795
For research use only
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