A 582941
Tocris Bioscience, part of Bio-Techne | Catalog # 4341
α7 nAChR partial agonist
Key Product Details
Description
α7 nAChR partial agonist
Product Description
A 582941 is a selective α7 nAChR partial agonist; exhibits high affinity for both rat and human α7 receptors (Ki values are 10.8 and 16.7 nM respectively). Displays ~15-fold selectivity for α7 over 5-HT3 receptors (Ki = 150 nM for 5-HT3).Product Specifications
Molecular Weight
280.37
Formula
C17H20N4
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
Octahydro-2-methyl-5-(6-phenyl-3-pyridazinyl)-pyrrolo[3,4-c]pyrrole
CAS Number
848591-90-2
PubChem ID
44190553
InChI Key
GTMRUYCIJSNXGB-GASCZTMLSA-N
SMILES
[H][C@@]12[C@@](CN(C3=CC=C(C4=CC=CC=C4)N=N3)C2)([H])CN(C)C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 14.02 | 50 | |
| DMSO | 28.04 | 100 |
Preparing Stock Solutions
for A 582941
The following data is based on the product molecular weight 280.37
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.57 mL | 17.83 mL | 35.67 mL |
| 5 mM | 0.71 mL | 3.57 mL | 7.13 mL |
| 10 mM | 0.36 mL | 1.78 mL | 3.57 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.71 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
Product Specific Notices for A 582941
For research use only
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