21 results for "GTPase Inhibitors Small Molecules and Peptides" in Products
GTPase Inhibitors: Small Molecules and Peptides
GTPases are a large group of enzymes that catalyze hydrolysis of the γ phosphate bond in guanine triphosphate (GTP) to form guanine diphosphate (GDP). Mg2+ is essential for catalytic activity. GTPases have essential roles in signal transduction, protein synthesis and translocation, control of cell growth and differentiation and vesicular transport regulation.
There are six main families of GTPases; heterotrimeric G protein GTPases (E.C. 3.6.5.1), small monomeric GTPases (E.C. 3.6.5.2), protein-synthesizing (translational) GTPases (E.C. 3.6.5.3), signal-recognition-particle GTPase (E.C. 3.6.5.4), dynamin GTPases (E.C. 3.6.5.5) and tubulin GTPases (E.C. 3.6.5.6).
Non-competitive dynamin inhibitor
| Chemical Name: | 3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazide |
| Purity: | ≥98% (HPLC) |
Selective dynamin inhibitor; attenuates mitochondrial division and apoptosis
| Chemical Name: | 3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone |
| Purity: | ≥98% (HPLC) |
Potent Rac family inhibitor
| Chemical Name: | 5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride |
| Purity: | ≥98% (HPLC) |
Selective inhibitor of Rac1-GEF interaction; antioncogenic
| Chemical Name: | N6-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrochloride |
| Purity: | ≥98% (HPLC) |
Potent farnesyl diphosphate (FPP) synthase inhibitor
| Alternate Names: | Zometa |
| Chemical Name: | [1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid |
| Purity: | ≥98% (HPLC) |
Selective Cdc42 Rho family inhibitor
| Alternate Names: | CID 2950007 |
| Chemical Name: | 4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]benzenesulfonamide |
| Purity: | ≥98% (HPLC) |
Gα-protein inhibitor; potent inhibitor of Gq/11 signaling
| Chemical Name: | (R)-1-((3S,6S,9S,12S,18R,21S,22R)-21-acetamido-18-benzyl-3-((R)-1-methoxyethyl)-4,9,10,12,16,22-hexamethyl-15-methylene-2,5,8,11,14,17,20-heptaoxo-1,19-dioxa-4,7,10,13,16-pentaazacyclodocosan-6-yl)-2-methylpropyl (2S,3R)-2-acetamido-3-hydroxy-4-methylpentanoate |
| Purity: | ≥95% (HPLC) |
Rho inhibitor
| Chemical Name: | D-Tryptophan (2E)-2-(6-quinoxalinylmethylene)hydrazide hydrochloride |
| Purity: | ≥98% (HPLC) |
Rac inhibitor
| Chemical Name: | N4-(9-Ethyl-9H-carbazol-3-yl)-N2-[3-(4-morpholinyl)propyl]-2,4-pyrimidinediamine |
| Purity: | ≥98% (HPLC) |
Dynamin I inhibitor
| Chemical Name: | 2-Cyano-3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-N-octyl-2-propenamide |
| Purity: | ≥98% (HPLC) |
DOCK2-Rac1 interaction inhibitor
| Chemical Name: | 4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione |
| Purity: | ≥98% (HPLC) |
Selectively kills mutant HRAS-expressing cells; glutathione peroxidase inhibitor; induces ferroptosis
| Chemical Name: | [4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)methanone |
| Purity: | ≥98% (HPLC) |
Epac inhibitor
| Chemical Name: | α-[(2-(3-Chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-β-oxo-3-isoxazolepropanenitrile |
| Purity: | ≥98% (HPLC) |
Selective ARF6 inhibitor
| Chemical Name: | 3-(4-Chlorophenyl)-5-(4-nitrophenyl)-2-(phenylmethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one |
| Purity: | ≥98% (HPLC) |
Dynamin-related protein 1 (Drp1) inhibitor; cell-permeable
| Purity: | ≥95% (HPLC) |
Geranylgeranyltransferase-I (GGTase-I) inhibitor
| Chemical Name: | (2R)-3,3,3-Trifluoro-2-methoxy-1-[(7R)-7-(2-methoxyphenyl)-3,9-diazaspiro[5.5]undec-3-yl]-2-phenyl-1-propanone hydrochloride |
| Purity: | ≥98% (HPLC) |
Dynamin inhibitor; analog of dynasore (Cat. No. 2897)
| Alternate Names: | Dyngo 4a |
| Chemical Name: | 3-Hydroxynaphthalene-2-carboxylic acid 2-[(2,4,5)-trihydroxyphenyl)methylene]hydrazide |
| Purity: | ≥98% (HPLC) |
High affinity PDEδ-KRas interaction inhibitor; binds to PDEδ
| Chemical Name: | 2-[4-[(2S)-2-(2-Phenyl-1H-benzimidazol-1-yl)-2-(4-piperidinyl)ethoxy]phenyl]-1-(phenylmethyl)-1H-benzimidazole trihydrochloride |
| Purity: | ≥98% (HPLC) |
Selective Epac2 inhibitor
| Chemical Name: | 2,4-Dimethyl-1-[(2,4,6-trimethylphenyl)sulfonyl]-1H-pyrrole |
| Purity: | ≥98% (HPLC) |
Epac2 inhibitor
| Chemical Name: | 1,3,5-Trimethyl-2-[(4-methylphenyl)sulfonyl]benzene |
| Purity: | ≥98% (HPLC) |
Potent covalent inhibitor of the RAS domain of the PI3K/p110α interaction
| Chemical Name: | 5-((1R,2S,5S)-2-(2-Chloro-3-fluorophenyl)-3-azabicyclo[3.1.0]hexan-3-yl)-N-((R,E)-4-(methylsulfonyl)but-3-en-2-yl)pyrazine-2-carboxamide |
| Purity: | ≥98% (HPLC) |
