EHop 016

Tocris Bioscience, part of Bio-Techne | Catalog # 6248

Rac inhibitor
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Key Product Details

Description

Rac inhibitor

View all Rho GTPase Inhibitors »

Product Description

EHop 016 is a Rac inhibitor (IC50 = 1.1 μM). Exhibits some selectivity for Rac1 and Rac3 over Cdc42. Blocks the interaction of Rac with guanine nucleotide exchange factor Vav2 in breast cancer cell lines expressing high levels of Rac activity and inhibits activity of Rac downstream effector PAK1. Also inhibits mammary tumor growth and metastasis in mice.

Product Specifications

Molecular Weight

430.55

Formula

C25H30N6O

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N4-(9-Ethyl-9H-carbazol-3-yl)-N2-[3-(4-morpholinyl)propyl]-2,4-pyrimidinediamine

CAS Number

1380432-32-5

PubChem ID

51031035

InChI Key

AFTZZRFCMOAFCR-UHFFFAOYSA-N

SMILES

CCN1C2=CC=C(NC3=NC(NCCCN4CCOCC4)=NC=C3)C=C2C5=CC=CC=C51

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.53 50

Preparing Stock Solutions for EHop 016

The following data is based on the product molecular weight 430.55

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.65 mL 23.23 mL 46.45 mL
2.5 mM 0.93 mL 4.65 mL 9.29 mL
5 mM 0.46 mL 2.32 mL 4.65 mL
25 mM 0.09 mL 0.46 mL 0.93 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for EHop 016

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for EHop 016

For research use only

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