Rhosin hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 5003
Rho inhibitor
Product Description
Rhosin hydrochloride is a Rho GTPase inhibitor (Kd = 354 nM). Inhibits binding of RhoA to guanine nucleotide exchange factors (GEFs) including LARG, DBL, LBC, p115 RhoGEF and PDZ RhoGEF. Has no effect on the binding of Rac1 or Cdc42 to their respective GEFs. Suppresses RhoA/C-mediated breast cancer cell migration and invasion in vitro. Also induces neurite outgrowth in synergy with NGF.Product Specifications
Molecular Weight
394.86
Formula
C20H18N6O.HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
D-Tryptophan (2E)-2-(6-quinoxalinylmethylene)hydrazide hydrochloride
CAS Number
1281870-42-5
PubChem ID
44662615
InChI Key
SFRGBDFQSLZYLF-GRYLRVQNSA-N
SMILES
N[C@@H](C(N/N=C/C3=CC=C(N=CC=N4)C4=C3)=O)CC2=CNC1=CC=CC=C12.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 7.9 | 20 with gentle warming | |
| DMSO | 39.49 | 100 |
Preparing Stock Solutions
for Rhosin hydrochloride
The following data is based on the product molecular weight 394.86
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.53 mL | 12.66 mL | 25.33 mL |
| 5 mM | 0.51 mL | 2.53 mL | 5.07 mL |
| 10 mM | 0.25 mL | 1.27 mL | 2.53 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Shang Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases. Chem.Biol. 2012 PMID: 22726684
- Shang Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors. Proc.Natl.Acad.Sci.U.S.A. 2013 PMID: 23382194
Product Specific Notices for Rhosin hydrochloride
For research use only
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