BAY 593
Tocris Bioscience, part of Bio-Techne | Catalog # 8113
Geranylgeranyltransferase-I (GGTase-I) inhibitor
Key Product Details
Description
Geranylgeranyltransferase-I (GGTase-I) inhibitor
Product Description
BAY 593 is a geranylgeranyltransferase-I (GGTase-I) inhibitor. Blocks activation of Rho-GTPases to inactivate YAP1/TAZ signaling. Dose-dependently inhibits growth of tumors in xenograft mouse models (IC50 values are 38.4 nM and 564 nM in MT-1080 and MDA-MB-231 cells respectively) and PXF 541 xenografts. Orally bioavailable and suitable for use in vivo.Product Specifications
Molecular Weight
513.00
Formula
C26H31F3N2O3.HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(2R)-3,3,3-Trifluoro-2-methoxy-1-[(7R)-7-(2-methoxyphenyl)-3,9-diazaspiro[5.5]undec-3-yl]-2-phenyl-1-propanone hydrochloride
CAS Number
2413020-57-0
InChI Key
OCVVGTVEVMMMCR-XSHMPXIGSA-N
SMILES
COC1=C(C=CC=C1)[C@H]2C3(CCNC2)CCN(CC3)C([C@](OC)(C4=CC=CC=C4)C(F)(F)F)=O.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 51.3 | 100 |
Preparing Stock Solutions
for BAY 593
The following data is based on the product molecular weight 513.00
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.95 mL | 9.75 mL | 19.49 mL |
| 5 mM | 0.39 mL | 1.95 mL | 3.90 mL |
| 10 mM | 0.19 mL | 0.97 mL | 1.95 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.39 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Graham Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling. Cell.Chem.Biol. 2024 PMID: 38537632
Product Specific Notices for BAY 593
For research use only
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