Deltarasin
Tocris Bioscience, part of Bio-Techne | Catalog # 5424
High affinity PDEδ-KRas interaction inhibitor; binds to PDEδ
Key Product Details
Description
High affinity PDEδ-KRas interaction inhibitor; binds to PDEδ
Product Description
Deltarasin is a high affinity PDEδ-KRAS interaction inhibitor (Kd = 41 nM); binds to PDEδ. Reduces proliferation and induces cell death of KRAS-dependent Panc-Tu-1 and Capan-1 pancreatic cancer cells. Attenuates tumor growth of Panc-Tu-1 xenografts in mice.Product Specifications
Molecular Weight
713.14
Formula
C40H37N5O.3HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-[4-[(2S)-2-(2-Phenyl-1H-benzimidazol-1-yl)-2-(4-piperidinyl)ethoxy]phenyl]-1-(phenylmethyl)-1H-benzimidazole trihydrochloride
CAS Number
1440898-82-7
PubChem ID
91826089
InChI Key
NCIOVAYUMQEQEU-VKZSUDIWSA-N
SMILES
C12=CC=CC=C1N=C(C4=CC=C(OC[C@H]([C@H]8CCNCC8)N5C(C7=CC=CC=C7)=NC6=C5C=CC=C6)C=C4)N2CC3=CC=CC=C3.Cl.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 71.31 | 100 | |
| DMSO | 71.31 | 100 |
Preparing Stock Solutions
for Deltarasin
The following data is based on the product molecular weight 713.14
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.40 mL | 7.01 mL | 14.02 mL |
| 5 mM | 0.28 mL | 1.40 mL | 2.80 mL |
| 10 mM | 0.14 mL | 0.70 mL | 1.40 mL |
| 50 mM | 0.03 mL | 0.14 mL | 0.28 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Zimmermann Structure guided design and kinetic analysis of highly potent benzimidazole inhibitors targeting the PDEδ prenyl binding site. J.Med.Chem. 2014 PMID: 24884780
- Zimmermann Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling. Nature 2013 PMID: 23698361
Product Specific Notices for Deltarasin
For research use only
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