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Simple Plex™ Assays for Inflammatory Biomarker Research

See how Simple Plex assays on the EllaTM platform are used to profile inflammatory biomarkers. Next, meet Ella and request pricing. Finally, choose the Simple Plex Assay that best meets your needs.

Table of Contents

Next Gen Immunoassays For Immune Reactivity And Inflammation Research

The systemic cytokine and chemokine cascades set off by acute inflammatory responses require a fast, sensitive and standardized immunoassay format to profile accurately. Automated Simple Plex™ assays on Ella™ get you that critical immune reactivity information and inflammation status data by simply adding your sample and buffers to a cartridge and pressing Start.

Whether you're a researcher tackling cytokine release syndrome, sepsis, the pertinent COVID-19 pandemic, or other acute respiratory failure research, reliably monitoring the inflammatory response is the crux of your ability to make informed decisions. And Ella delivers the results you need, fast.


joint inflammation

Real-Time, Standardized Biomarker Profiling

  • With a total time to result of just 90 minutes, Ella gives you readouts in a fraction of the time of a manual assay
  • Ella ensures the standardization of your immunoassay, as everything is exclusively pre-packaged, pre-optimized, and pre-loaded
  • With a four-log range of detection, Simple Plex assays have the sensitivity to pick up even very low picogram-per-milliliter levels of endogenous analyte



From Your Peers

Michael Matthay uses Ella to identify biomarkers important in acute respiratory failure and sepsis

Ella Promises Better Clinical Care For Acute Respiratory Failure And Sepsis

"Timely results from Ella have the potential to direct treatment for acute diseases where administration needs to take place in a matter of hours."

- Michael Matthay, M.D., Ph.D., Professor of Medicine, University of California San Francisco

Dr. E. Scott Halstead  uses Ella to profile inflammatory biomarkers in pneumonia

Simplifying And Expediting Inflammatory Biomarker Research With Ella

"Ella is the closest I’ve seen to my goal of one day having a Star Trek-like tricorder. I can take just 25 μL of serum, add it to a cartridge, and in 90 minutes have immune profiling data."

- E. Scott Halstead, M.D., Ph.D., Associate Professor, Department of Pediatrics, Penn State University College of Medicine



Ella Characterizes Cytokine Release Syndrome Biomarkers In Car T-Cell Therapy

Correlating biomarkers with clinical evidence is essential for the safe delivery of CAR T-cell therapies, and, therefore, for the full realization of their therapeutic potential. To do this, fast and accurate evaluation and monitoring of the immune response is necessary. Download this poster to see how researchers at Moffit Cancer Center use Ella to quantitate relevant biomarker levels in the serum of CAR T donors compared with healthy controls.

Download the CRS in CAR T Therapy Poster


Fast And Reproducible Quantitation Of Cytokines With Ella

Manual immunoassay workflows are error-prone and struggle with reproducibility and variability of results—results that take hours of time to produce and analyze. Not with Ella. Download this application note for a glimpse of peer-reviewed work from researchers around the globe using Ella to reliably and quickly measure cytokines.

Download the Reproducible Quantitation of Cytokines With Ella Application Note



More Of Simplex Plex In The Inflammation Research Literature

Learn how Ella is already advancing inflammatory biomarker research.

Simple Plex Assays For Inflammation Research

These analytes are key for monitoring immune reactivity and have been implicated in acute inflammatory responses to pathologies such as cytokine release syndrome, sepsis, COVID-19, and acute respiratory distress syndrome. View our exclusive COVID-19 panel and package.

Simple Plex Inflammatory Markers
C-Reactive Protein (CRP) Eotaxin-3/CCL26 IL-6 2nd Gen MCP-1/CCL2
CCL18/PARC ICAM-1 IL-6 R-alpha MIF
CCL19/MIP-3 beta IFN-gamma 3rd Gen IL-8 MIP-1 alpha/CCL3
CCL2/MCP-1 IL-1-alpha IL-10 MIP-1 beta/CCL4
CCL5/RANTES IL-1-beta IL-12p70 Pentraxin 3/TSG-14
CD25/IL-2 R alpha IL-1ra/IL-1F3 IL-17A TNF alpha 2nd Gen
CXCL12/SDF-1 alpha IL-2 IL-18 TREM-1
E-Selectin IL-2 R alpha/CD25 IL-18Bpa  
ENA-78/CXCL5 IL-4 IL-22

The Industry Leader In Quality

Simple Plex assays are developed by the industry leader in immunoassays, R&D Systems, so you know a high level of quality and validation is behind Ella, and will provide you with the analytical power and assay sensitivity needed to support your inflammation research.

  • Brought to you by the makers of Quantikine® ELISA kits, Simple Plex assays continue a legacy of quality immunoassays
  • Our vertically integrated supply chain ensures you get the same results years into the future
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Fully Automated Immunoassays on Ella

Meet Ella

Browse the full Simple Plex assay menu, see how Ella works, or talk to one of our Immunoassay specialists about inflammatory biomarker assay solutions for your lab.

Simple Plex Applications

sars cov-2 virus

COVID-19 Research

Quantify cytokine and pro-inflammatory responses to SARS-CoV-2 infection in 90 minutes using an automated, multianalyte format.

joint inflammation

Inflammation Research

Simple Plex assays enable rapid and reproducible quantification of inflammatory responses such as cytokine release syndrome and sepsis. 

immune cells attack cancer cell

Cancer Biomarker Research

Simple Plex assays for cancer research have the sensitivity to profile low abundance cancer biomarkers.

neuronal network

Neuroscience Research

Measure key neuroscience biomarkers such as neurofilament light (NF-L) and neurofilament heavy (NF-H) in CSF, plasma, and serum.

Cell and gene therapy

Cell Therapy Research and Development

The Simple Plex HEK 293 HCP 3G assay on the Ella platform offers broad detection coverage of this host cell protein (HCP).

protein bioprocessing workflow

Bioprocess Testing

Iterate your workflow faster with Simple Plex CHO HCP 3G-1 assays for process-related impurity testing.

preclinical scientist pipetting in the lab

Preclinical Research

With a four-log range of detection, Simple Plex assays have the sensitivity to pick up even very low picogram-per-milliliter levels of endogenous mouse or rat analytes.

AAV2 virus for simple plex

Viral Titer Assays

Get highly reproducible adeno-associated virus and lentivirus titer data with no manual steps in just 90 minutes.

Simple Plex Cartridge Denominations

Automated ELISA platform assay options including singleplex, multianalyte and multiplex assay cartridges



  16x1 32x1 16x2 16x3 16x4 32x2 72x1 32x3 32x4 32x5 32x6 32x7 32x8
Samples 16 32 16 16 16 32 72 32 32 32 32 32 32
Plex 1 1 2 3 4 2 1 3 4 5 6 7 8
Replicates 3 3 3 3 3 3 3 3 3 2 2 2 2
Reportable Results 16 32 32 48 64 64 72 96 128 160 192 224 256