Ubiquitin Ligase (E3) Inhibitors: Small Molecules and Peptides
39 results for "Ubiquitin Ligase (E3) Inhibitors Small Molecules and Peptides" in Products
39 results for "Ubiquitin Ligase (E3) Inhibitors Small Molecules and Peptides" in Products
Ubiquitin Ligase (E3) Inhibitors: Small Molecules and Peptides
HECT E3 ubiquitin ligase inhibitor
| Chemical Name: | N-(4-Acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide |
| Purity: | ≥98% (HPLC) |
Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase
| Chemical Name: | 3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione |
| Purity: | ≥98% (HPLC) |
SPOP E3 ubiquitin ligase inhibitor
| Chemical Name: | 1,5-Dihydro-2-imino-10-methyl-N-[2-(4-methyl-1-piperazinyl)ethyl]-5-oxo-1-[2-(2-thienyl)ethyl]-2H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide |
| Purity: | ≥98% (HPLC) |
Selective Skp2 inhibitor; suppresses E3 ligase activity
| Chemical Name: | 3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one |
| Purity: | ≥98% (HPLC) |
(+)-JQ1 based PROTAC® with selectivity for BRD4
| Chemical Name: | (2S,4R)-1-(2R)-2-Acetamido-3-[[6-[2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetamido]hexyl]thio]-3-methylbutanoyl]-4-hydroxy-N-[4-(4-methylthiazol-5-yl)benzyl)pyrrolidinine-2-carboxamide |
| Purity: | ≥98% (HPLC) |
Cdc20 inhibitor; inhibits Cdc20-substrate interaction
| Chemical Name: | 3-(2-Methyl-5-nitroimidazol-1-yl)-N-(2,2,2-trichloro-1-phenylaminoethyl)propionamide |
| Purity: | ≥98% (HPLC) |
Potent and selective CSN5 (COP9 signalosome) inhibitor
| Chemical Name: | 3-(Difluoromethyl)-N-(6-((5S,6S)-6-hydroxy-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]azepin-5-yl)-[1,10-biphenyl]-3-yl)-1-isopropyl-1H-pyrazole-5-carboxamide |
| Purity: | ≥98% (HPLC) |
MDM2-p53 interaction inhibitor
| Alternate Names: | NSC 652287 |
| Chemical Name: | 5,5'-(2,5-Furandiyl)bis-2-thiophenemethanol |
| Purity: | ≥97% (HPLC) |
Selective GID4 antagonist
| Chemical Name: | N-((1s,4s)-4-(1H-Benzo[d]imidazol-2-yl)cyclohexyl)-2-(((1H-indol-2-yl)methyl)amino)acetamide dihydrochloride |
| Purity: | ≥98% (HPLC) |
Cereblon binder; also TNF-α inhibitor and antiangiogenic
| Chemical Name: | 4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |
| Purity: | ≥98% (HPLC) |
Selective CUL4 inhibitor
| Chemical Name: | 3-[1-(4-Chlorophenyl)-1H-pyrazol-4-yl]-7,8-dihydroxy-2-(trifluoromethyl)-4H-1-benzopyran-4-one |
| Purity: | ≥98% (HPLC) |
MDM2 antagonist; inhibits MDM2-p53 interaction
| Chemical Name: | (±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one |
| Purity: | ≥98% (HPLC) |
CHIP/STUB1 E3 ligase inhibitor
| Purity: | ≥95% (HPLC) |
SKP2 (S-phase kinase-associated protein 2) inhibitor; upregulates p27 and arrests cell cycle in G1 phase
| Chemical Name: | N-(4-Butyl-2-methylphenyl)acetamide |
| Purity: | ≥98% (HPLC) |
MDM2 antagonist; active enantiomer of Nutlin-3 (Cat. No. 3984)
| Chemical Name: | 4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone |
| Purity: | ≥97% (HPLC) |
β-TrCP1 ligase inhibitor
| Chemical Name: | 4-[4-[[5-(2-Fluorophenyl)-2-furanyl]methylene]-4,5-dihydro-5-oxo-3-(phenylmethyl)-1H-pyrazol-1-yl]benzoic acid |
| Purity: | ≥98% (HPLC) |
(+)-JQ1 based Degrader (PROTAC®) targeting BET bromodomains, active in vivo
| Chemical Name: | (6S)-4-(4-Chlorophenyl)-N-[4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]butyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide |
| Purity: | ≥98% (HPLC) |
RNF114 inhibitor
| Chemical Name: | (2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-8-(3-Furanyl)-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2a,5a,6a,7-tetramethyl-2,5-dioxo-2H,5H-cyclopenta[d']naphtho[1,8-bc:2,3-b']difuran-6-acetic acid methyl ester |
| Purity: | ≥97% (HPLC) |
High-affinity inhibitor of VHL
| Chemical Name: | (2S,4R)-1-((S)-2-(1-cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
| Purity: | ≥98% (HPLC) |
Homo-PROTAC® for self-degradation of pVHL30
| Chemical Name: | N1,N20-bis((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,6,9,12,15,18-hexaoxaicosanediamide |
| Purity: | ≥98% (HPLC) |
Hdm2 inhibitor; activates p53-dependent transcription
| Chemical Name: | 5-[[3-Dimethylamino)propyl]amino]-3,10-dimethylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione dihydrochloride |
| Purity: | ≥99% (HPLC) |
Inhibitor of Bmi1/Ring1A; blocks histone H2A ubiquitination
| Chemical Name: | 2-(3-Pyridinylmethylene)-1H-Indene-1,3(2H)-dione |
| Purity: | ≥99% (HPLC) |
Negative control for CSN5i-3 (Cat. No. 7089)
| Chemical Name: | 3-(Difluoromethyl)-N-(6-((5R,6R)-6-hydroxy-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]azepin-5-yl)-[1,10-biphenyl]-3-yl)-1-isopropyl-1H-pyrazole-5-carboxamide |
| Purity: | ≥98% (HPLC) |
High affinity MDM2 inhibitor
| Chemical Name: | 6-Methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole |
| Purity: | ≥98% (HPLC) |
Potent MDM2 inhibitor; inhibits MDM2-p53 interaction
| Chemical Name: | 4-[[[(2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-2-pyrrolidinyl]carbonyl]amino]-3-methoxybenzoic acid |
| Purity: | ≥98% (HPLC) |
