CHIPOpt

Name: CHIPOpt
Brand: Tocris Bioscience
SKU: 8044

Tocris Bioscience, part of Bio-Techne | Catalog # 8044

COA / SDS

CHIP/STUB1 E3 ligase inhibitor

Key Product Details

Description:	CHIP/STUB1 E3 ligase inhibitor
Purity:	≥95% (HPLC)
Molecular Weight:	757.84

View Full Technical Details for CHIPOpt

Technical Data
Citations

Biological Activity for CHIPOpt

CHIPOpt is a CHIP/STUB1 E3 ligase inhibitor. In vitro, CHIPOpt decreases phosphorylated tau ubiquitination, with little effect on unmodified tau. In Thioflavin T assays, CHIPOpt inhibits the ability of CHIP to suppress phosphorylated tau aggregation. FITC-CHIPOpt (Cat. No. 8045), a fluorescent CHIPOpt, is also available.

Technical Data for CHIPOpt

M. Wt	757.84
Formula	C₃₉H₄₇N₇O₉
Single Letter Sequence	LWWPD (Modification: Leu-1 = N-terminal Ac)
Storage	Store at -20°C
Purity	≥95% (HPLC)
InChi Key	NAUYSEKQVONAJC-ZTTXAYQISA-N
Smiles	O=C(N[C@@H](CC(C)C)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N5[C@@H](CCC5)C(N[C@@H](CC(O)=O)C(O)=O)=O)=O)=O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CHIPOpt

Solubility

Soluble to 2mg/ml in 0.01M PBS

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References for CHIPOpt

References are publications that support the biological activity of the product.

Ravalin Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases. Nat.Chem.Biol. 2019 PMID: 31320752
Nadel The E3 ubiquitin ligase, CHIP/STUB1, inhibits aggregation of phosphorylated proteoforms of microtubule-associated protein tau (MAPT). J.Mol.Biol. 2023 PMID: 37330289