CHIPOpt

Tocris Bioscience, part of Bio-Techne | Catalog # 8044

CHIP/STUB1 E3 ligase inhibitor
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Key Product Details

Description

CHIP/STUB1 E3 ligase inhibitor

View all Ubiquitin Ligase (E3) Inhibitors »

Product Description

CHIPOpt is a CHIP/STUB1 E3 ligase inhibitor. In vitro, CHIPOpt decreases phosphorylated tau ubiquitination, with little effect on unmodified tau. In Thioflavin T assays, CHIPOpt inhibits the ability of CHIP to suppress phosphorylated tau aggregation. FITC-CHIPOpt (Cat. No. 8045), a fluorescent CHIPOpt, is also available.

Product Specifications

Molecular Weight

757.84

Formula

C39H47N7O9

Storage

Store at -20°C

Purity

≥95% (HPLC)

InChI Key

NAUYSEKQVONAJC-ZTTXAYQISA-N

SMILES

O=C(N[C@@H](CC(C)C)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N5[C@@H](CCC5)C(N[C@@H](CC(O)=O)C(O)=O)=O)=O)=O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 2mg/ml in 0.01M PBS

Calculators

Molarity Calculator

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for CHIPOpt

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CHIPOpt

For research use only

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