FITC-CHIPOpt

Name: FITC-CHIPOpt
Brand: Tocris Bioscience
SKU: 8045

Tocris Bioscience, part of Bio-Techne | Catalog # 8045

COA / SDS

Fluorescent CHIP/STUB1 E3 ligase inhibitor

Discontinued Product

8045 has been discontinued. View all Fluorescent Probes products.

Key Product Details

Description:	Fluorescent CHIP/STUB1 E3 ligase inhibitor
Purity:	≥95% (HPLC)
Molecular Weight:	1218.35

View Full Technical Details for FITC-CHIPOpt

Technical Data
Citations

Biological Activity for FITC-CHIPOpt

FITC-CHIPOpt is a fluorescent CHIP/STUB1 E3 ligase inhibitor. It binds to CHIP and can be used in CHIP fluorescent polarization (FP) binding assays. Enables CHIP FP binding assays to be developed for new inhibitor or CHIP ligand synthesis. FITC-CHIPOpt is the fluorescent version of CHIPOp (Cat. No. 8044).

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Technical Data for FITC-CHIPOpt

M. Wt	1218.35
Formula	C₆₄H₆₇N₉O₁₄S
Single Letter Sequence	XLWWPD (Modifications: X-1 = FTIC-6-aminohexanoic acid
Storage	Store at -20°C
Purity	≥95% (HPLC)
InChi Key	WHLHAYSAZOFWTL-TVKYAJOTSA-N
Smiles	O=C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N5[C@@H](CCC5)C(N[C@@H](CC(O)=O)C(O)=O)=O)=O)=O)[C@H](CC(C)C)NC(CCCCCNC(NC(C=C6C(O)=O)=CC=C6C(C7=C8C=C(O)C=C7)=C(C=C9)C(O8)=CC9=O)=S)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for FITC-CHIPOpt

References are publications that support the biological activity of the product.

Ravalin Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases. Nat.Chem.Biol. 2019 PMID: 31320752
Nadel The E3 ubiquitin ligase, CHIP/STUB1, inhibits aggregation of phosphorylated proteoforms of microtubule-associated protein tau (MAPT). J.Mol.Biol. 2023 PMID: 37330289