Product Description
VL 285 is an E3 ubiquitin ligase VHL inhibitor (IC50= 340 nM). VL 285 treatment competitively reduces or reverses target protein degradation by AU-15330 and HaloPROTAC3 Degraders.Product Specifications
Molecular Weight
532.66
Formula
C29H32N4O4S
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
(2S,4R)-4-Hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
CAS Number
1448188-57-5
PubChem ID
71667162
InChI Key
HEDFFPYRFJKXQP-VJTSUQJLSA-N
SMILES
CC1=C(C2=CC=C(CNC([C@H]3N(C([C@@H](N4CC(C=CC=C5)=C5C4=O)C(C)C)=O)C[C@H](O)C3)=O)C=C2)SC=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.63 | 50 | |
| Ethanol | 10.65 | 20 |
Preparing Stock Solutions
for VL 285
The following data is based on the product molecular weight 532.66
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.75 mL | 18.77 mL | 37.55 mL |
| 2.5 mM | 0.75 mL | 3.75 mL | 7.51 mL |
| 5 mM | 0.38 mL | 1.88 mL | 3.75 mL |
| 25 mM | 0.08 mL | 0.38 mL | 0.75 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Xiao Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer. Nature 2022 PMID: 34937944
- Buckley HaloPROTACS: use of small molecule PROTACs to induce degradation of HaloTag fusion proteins. ACS Chem.Biol. 2015 PMID: 26070106
Product Specific Notices for VL 285
For research use only
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