Heclin
Tocris Bioscience, part of Bio-Techne | Catalog # 5433
HECT E3 ubiquitin ligase inhibitor
Key Product Details
Description
HECT E3 ubiquitin ligase inhibitor
Product Description
Heclin is a HECT E3 ubiquitin ligase inhibitor; inhibits Nedd4, Smurf2 and WWP1 (IC50 values are 6.3, 6.8 and 6.9 μM respectively). Selective for HECT-mediated over RING-mediated ubiquitination.Product Specifications
Molecular Weight
283.32
Formula
C17H17NO3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-(4-Acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide
CAS Number
890605-54-6
PubChem ID
7464118
InChI Key
SPTWXRJNCFIDRQ-ZHACJKMWSA-N
SMILES
CC(C1=CC=C(NC(/C=C/C2=CC=C(CC)O2)=O)C=C1)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.33 | 100 | |
| Ethanol | 14.17 | 50 |
Preparing Stock Solutions
for Heclin
The following data is based on the product molecular weight 283.32
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.53 mL | 17.65 mL | 35.30 mL |
| 5 mM | 0.71 mL | 3.53 mL | 7.06 mL |
| 10 mM | 0.35 mL | 1.76 mL | 3.53 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.71 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Mund Peptide and small molecule inhibitors of HECT-type ubiquitin ligases. Proc.Natl.Acad.Sci.U.S.A. 2014 PMID: 25385595
Product Specific Notices for Heclin
For research use only
Loading...
Loading...