Apcin
Tocris Bioscience, part of Bio-Techne | Catalog # 5747
Cdc20 inhibitor; inhibits Cdc20-substrate interaction
Key Product Details
Description
Cdc20 inhibitor; inhibits Cdc20-substrate interaction
Product Description
Apcin is a Cdc20 inhibitor; inhibits Cdc20-substrate interaction. Blocks substrate-mediated Cdc20 loading onto the anaphase-promoting complex (APC). Inhibits APC-dependent ubiquitylation. Prolongs mitotic duration in RPE1 cells in combination with proTAME (prodrug of TAME (Cat.No. 4506)) in vitro.Product Specifications
Molecular Weight
438.65
Formula
C13H14Cl3N7O4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
3-(2-Methyl-5-nitroimidazol-1-yl)-N-(2,2,2-trichloro-1-phenylaminoethyl)propionamide
CAS Number
300815-04-7
PubChem ID
2830389
InChI Key
ZEXHXVOGJFGTRX-UHFFFAOYSA-N
SMILES
CC1=NC=C([N+]([O-])=O)N1CCOC(NC(C(Cl)(Cl)Cl)NC2=NC=CC=N2)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.87 | 100 |
Preparing Stock Solutions
for Apcin
The following data is based on the product molecular weight 438.65
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.28 mL | 11.40 mL | 22.80 mL |
| 5 mM | 0.46 mL | 2.28 mL | 4.56 mL |
| 10 mM | 0.23 mL | 1.14 mL | 2.28 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wang Targeting Cdc20 as a novel cancer therapeutic strategy. Pharmacol.Ther. 2015 PMID: 25850036
- Sackton Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C. Nature 2014 PMID: 25156254
Product Specific Notices for Apcin
For research use only
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