TAME hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 4506

Ubiquitin ligase APC/C inhibitor; promotes Cdc20 autoubiquitination
Discontinued Product
4506 has been discontinued. View all Ubiquitin Ligase (E3) Inhibitors products.

Key Product Details

Description

Ubiquitin ligase APC/C inhibitor; promotes Cdc20 autoubiquitination

View all Ubiquitin Ligase (E3) Inhibitors »

Product Description

TAME hydrochloride is a competitive inhibitor of the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C); promotes Cdc20 autoubiquitination. Inhibits cyclin proteolysis in mitotic Xenopus oocyte extracts (IC50 = 12 μM) and blocks cyclin degradation in interphase extract.

Product Specifications

Molecular Weight

378.87

Formula

C14H22N4O4S.HCl

Storage

Store at -20°C

Purity

≥99% (HPLC)

Chemical Name

N2-[(4-Methylphenyl)sulfonyl]-L-arginine methyl ester hydrochloride

CAS Number

1784-03-8

PubChem ID

2723792

InChI Key

JIQFFACVQXXHMY-YDALLXLXSA-N

SMILES

NC(NCCC[C@H](NS(C1=CC=C(C)C=C1)(=O)=O)C(OC)=O)=N.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 37.89 100
DMSO 37.89 100

Preparing Stock Solutions for TAME hydrochloride

The following data is based on the product molecular weight 378.87

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.64 mL 13.20 mL 26.39 mL
5 mM 0.53 mL 2.64 mL 5.28 mL
10 mM 0.26 mL 1.32 mL 2.64 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

Calculators

Molarity Calculator

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for TAME hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for TAME hydrochloride

For research use only

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