10 results for "Phospholipase Inhibitors Small Molecules and Peptides" in Products
Phospholipase Inhibitors: Small Molecules and Peptides
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes of phospholipases; phospholipase A (PLA) (E.C. 3.1.1.4), phospholipase B (E.C. 3.1.1.5), phosphoinositide-specific phospholipase C (PLC) (E.C. 3.1.4.11) and phospholipase D (PLD) (E.C. 3.1.4.50).
PLA is subdivided into PLA1 which cleave phospholipids at the sn-1 ester bond and PLA2, which cleave at the sn-2 bond. Their most common substrate is ...
Phospholipase C inhibitor
| Chemical Name: | 1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione |
| Purity: | ≥98% (HPLC) |
High affinity N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) inhibitor
| Chemical Name: | N-(Cyclopropylmethyl)-6-[(3S)-3-hydroxy-1-pyrrolidinyl]-2-[(3S)-3-phenyl-1-piperidinyl]-4-pyrimidinecarboxamide |
| Purity: | ≥98% (HPLC) |
Potent and selective cytosolic phospholipase A2 alpha (cPLA2α) inhibitor; active in vivo; orally bioavailable
| Chemical Name: | 3-(3-Phenethyl-1-(4-phenoxyphenyl)-1H-indol-5-yl)propanoic acid tris salt |
| Purity: | ≥98% (HPLC) |
Phospholipase A2 inhibitor
| Alternate Names: | Arachidonyl trifluoromethyl ketone |
| Chemical Name: | 1,1,1-Trifluoro-6Z,9Z,12Z,15Z-heneicosateraen-2-one |
Selective PC-PLC inhibitor
| Chemical Name: | O-(Octahydro-4,7-methano-1H-inden-5-yl) carbonopotassium dithioate |
| Purity: | ≥98% (HPLC) |
Potent lp-PLA2 inhibitor
| Chemical Name: | N-[2-(Diethylamino)ethyl]-2-[[(4-fluorophenyl)methyl]thio]-4,5,6,7-tetrahydro-4-oxo-N-[[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methyl]-1H-cyclopentapyrimidine-1-acetamide |
| Purity: | ≥98% (HPLC) |
Potent and selective PLD2 inhibitor
| Chemical Name: | N-[2-[1-(3-Fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-2-naphthalenecarboxamide |
| Purity: | ≥98% (HPLC) |
Analog of U 73122 (Cat. No. 1268)
| Chemical Name: | 1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-2,5-pyrrolidinedione |
| Purity: | ≥98% (HPLC) |
Diacylglycerol lipase inhibitor
| Alternate Names: | U 57908 |
| Chemical Name: | O,O'-[1,6-Hexanediylbis(iminocarbonyl)]dioxime cyclohexanone |
| Purity: | ≥95% (HPLC) |
Potent inhibitor of PLD1 and PLD2; CNS penetrant
| Chemical Name: | 4-Bromo-N-[(1S)-2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]-1-methylethyl]benzamide |
| Purity: | ≥98% (HPLC) |
