ML 299
Tocris Bioscience, part of Bio-Techne | Catalog # 4894
Potent inhibitor of PLD1 and PLD2; CNS penetrant
Key Product Details
Description
Potent inhibitor of PLD1 and PLD2; CNS penetrant
Product Description
ML 299 is a selective allosteric modulator and potent inhibitor of phospholipases D1 and D2 (IC50 values are 6 and 12 nM, respectively). ML 299 decreases invasive migration in glioblastoma cells and increases caspase 3/7 activity in serum-free conditions. ML 299 is non-cytotoxic, active in vivo and CNS penetrant.Product Specifications
Molecular Weight
489.39
Formula
C23H26BrFN4O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-Bromo-N-[(1S)-2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]-1-methylethyl]benzamide
CAS Number
1426916-00-8
PubChem ID
56593054
InChI Key
RFKXAYJUFUZBMA-INIZCTEOSA-N
SMILES
O=C(N[C@@H](C)CN1CCC2(C(NCN2C3=CC(F)=CC=C3)=O)CC1)C4=CC=C(Br)C=C4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 48.94 | 100 |
Preparing Stock Solutions
for ML 299
The following data is based on the product molecular weight 489.39
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.04 mL | 10.22 mL | 20.43 mL |
| 5 mM | 0.41 mL | 2.04 mL | 4.09 mL |
| 10 mM | 0.20 mL | 1.02 mL | 2.04 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.41 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
Product Specific Notices for ML 299
For research use only
Loading...
Loading...