VU 0364739 hydrochloride

Name: VU 0364739 hydrochloride
Brand: Tocris Bioscience
SKU: 4171

Tocris Bioscience, part of Bio-Techne | Catalog # 4171

Citations (9)

COA / SDS

Potent and selective PLD2 inhibitor

Key Product Details

Description:	Potent and selective PLD2 inhibitor
Chemical Name:	N-[2-[1-(3-Fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-2-naphthalenecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	482.98

View Full Technical Details for VU 0364739 hydrochloride

Technical Data
Citations

Biological Activity for VU 0364739 hydrochloride

VU 0364739 hydrochloride is a potent and selective phospholipase D2 (PLD2) inhibitor (IC₅₀ = 20 nM); displays 75-fold selectivity against PLD1 (IC₅₀ = 1500 nM).

Compound Libraries for VU 0364739 hydrochloride

VU 0364739 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for VU 0364739 hydrochloride

M. Wt	482.98
Formula	C₂₆H₂₇FN₄O₂.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1244640-48-9
PubChem ID	46939225
InChi Key	RYLAMDMOILNBKN-UHFFFAOYSA-N
Smiles	O=C(NCCN3CCC(C(NCN4C5=CC(F)=CC=C5)=O)4CC3)C2=CC1=CC=CC=C1C=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for VU 0364739 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	48.3	100

Preparing Stock Solutions for VU 0364739 hydrochloride

The following data is based on the product molecular weight 482.98.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.07 mL	10.35 mL	20.70 mL
5 mM	0.41 mL	2.07 mL	4.14 mL
10 mM	0.21 mL	1.04 mL	2.07 mL
50 mM	0.04 mL	0.21 mL	0.41 mL

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References for VU 0364739 hydrochloride

References are publications that support the biological activity of the product.

Lavieri Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)-ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor. J.Med.Chem.