LEI 401

Product Description

LEI 401 is a high affinity N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) inhibitor (K_i = 0.027 and 0.18 μM for human and mouse NAPE-PLD, respectively; IC₅₀ for human enzyme = 0.86 μM). LEI 401 exhibits no significant activity at cannabinoid receptors or other metabolic enzymes of the endocannabinoid system. The product reduces levels of N-acylethanolamines (NAE) in a neuroblastoma cell line in vitro. It also reduces anandamide levels in mouse brain in vivo and impairs fear extinction. LEI 701 is CNS penetrant and cell-permeable.

Licensing Information

Sold with kind permission of Professor van der Stelt

Solubility

Preparing Stock Solutions for LEI 401

The following data is based on the product molecular weight 421.55

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.37 mL	11.86 mL	23.72 mL
5 mM	0.47 mL	2.37 mL	4.74 mL
10 mM	0.24 mL	1.19 mL	2.37 mL
50 mM	0.05 mL	0.24 mL	0.47 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Mock Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice. Nat.Chem.Biol. 2020 PMID: 32393901